Let’s explore “Transsulfuration: from homocysteine to glutathione”

See how homocysteine connects to cysteine and glutathione. Follow seven simple steps, explore the side routes, and tap a word or building block to learn more.

Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

PURSER WELLNESSIs Your Fibromyalgia Affected by High Homocysteine?A conversation with Dr. Purser

🧬 High homocysteine isn’t just a heart problem—it’s a major player in fibromyalgia. If you’ve got fibro symptoms, there’s a good chance your transsulfuration pathway is broken—often due to 17 different SNPs or 12 key nutrient deficiencies. That means your body can’t detox properly or convert homocysteine into glutathione, leading to inflammation, pain, and fatigue. Don’t just chase labs—fix the root cause. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Homocysteine- one of the most inflammatory substances in the body - can’t be broken down and converted into Glutathione if you have this deficiency: B6. The transsulfuration pathway is broken if you don’t have sufficient B6 levels in your

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a tox…

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors Miss From the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire …

…al Deficiencies and Their Impact on Artificially Suppressed Homocysteine Levels Nutrition and unexpectedly low homocysteine The idea to explore Explore the chapter’s hypothesis that nutritional status can complicate interpretation of a lo…

This chapter connects genetic variation with the sulfur pathway that appears throughout Dr. Purser’s redox teaching.

Chapter 14: Homocysteine Elevation, Inflammatory Markers, Transsulfuration Pathway Disruption, and Toxicant Exposures in Genetic Hyperhomocysteinemia Homocysteine and environmental exposures The idea to explore This chapter places environ…

PURSER WELLNESSToxins Are Especially Bad For YOU!A conversation with Dr. Purser

Why do some people in the same family get destroyed by black mold… while others are completely fine? Why do two kids develop autism while their siblings are completely normal? Dr. Dan Purser explains the hidden genetic issue behind both: a homocysteine problem that disrupts the transsulfuration pathway — the pathway responsible for making ~90% of your glutathione. Without enough glutathione, your body simply cannot clear toxins. Mold, heavy metals, environmental chemicals… they stay stuck. This is why some people get chronically ill and others don’t, even when living in the exact same house. In this episode we cover: How a genetic disruption in the transsulfuration pathway causes low glutathione Why most “glutathione” products on Amazon do nothing The only two patented forms that actually work Real cases of black mold toxicity and autism improvement Why checking genetics is more important than just checking a homocysteine level This is root-cause medicine — not symptom chasing. Learn more: Website: https://danpursermd.com Two Glutathione: https://twoglutathione.com Substack: https://danpursermd.substack.com Office: (801) 796-7667 Email: info@danpursermd.com #Homocysteine #Glutathione #BlackMold #Autism #Detox #RootCauseMedicine #PurserWellness #Genetics

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.