Learning essentials

Interactive pathways · FROM DR. PURSER’S TEACHING

Transsulfuration: from homocysteine to glutathione

An interactive walk through CBS, CTH, cysteine and glutathione, with connected folate and choline routes. Explore the genes, nutrients and Dr. Purser’s teaching one step at a time.

Updated Sep 23, 2026 · Educational reference

AN INTERACTIVE PATHWAY

Follow the connections.

Choose a step to see what happens, which genes participate, and where nutrients fit.

Explore a connected branch:

Transsulfuration steps
100%

Scroll across the map on a smaller screen, or use the step buttons below.

Homocysteine, transsulfuration and glutathioneHomocysteine can return to methionine through folate or betaine routes. CBS and CTH connect homocysteine to cysteine. Cysteine then contributes to glutathione synthesis and other sulfur pathways. Choose any labeled step.SAM → SAHCTH / CSEantioxidant cycleMethionine cycleMethyl groups move throughthe cycleFolate routeHelps recycle homocysteineCholine / betaineAnother remethylation routeHomocysteineThe junction between tworoutesCystathionineCBS joins homocysteine +serineCysteineCTH / CSE releases cysteineOther sulfur routesTaurine, oxidation &signalingFirst building stepγ-glutamylcysteine isformedGlutathione · GSHGlycine completes themoleculeUse & recycleGSH ⇄ oxidized glutathione

A simplified teaching map. Arrows show biochemical connections, not measured pathway activity or a prediction from your SNPs. Cofactors shown here are not dosing recommendations.

THE TEACHING CONNECTION

Follow sulfur from homocysteine toward cysteine, then see how cysteine contributes to glutathione.

Two directions from homocysteine

Homocysteine can be recycled to methionine through remethylation or enter transsulfuration toward cysteine. The folate/B12 route and the choline/betaine route shown above belong to remethylation. CBS and CTH form the central transsulfuration sequence. This distinction helps explain why folate, B12, B6 and amino acids are related but do not all perform the same job.

How Dr. Purser connects the pathway

Dr. Purser brings this pathway into his homocysteine, genetics and antioxidant teaching. He considers the inherited pathway picture alongside current homocysteine, nutrient findings, symptoms, medicines and tolerance. Cysteine availability, glutathione production, antioxidant use and recycling are connected questions rather than interchangeable test results.

Where the VARS Triad and MTHFR Daily fit

In Dr. Purser’s treatment framework, the VARS Triad—VARS Glutathione, VARS SOD and VARS Catalase—together with MTHFR Daily is a central consideration when homocysteine or cytokine issues are involved. He emphasizes VARS Glutathione as a foundational functional-support component across his genetic SNP teaching. The individual gene lesson explains how its pathway connects to that broader approach.

This describes the Purser treatment model, not proof that a product corrects a variant or treats every associated condition. Product choice, formulation, sequence and amount depend on the individual assessment, existing medicines, current findings and tolerance.

Reading the map alongside your results

A common SNP does not prove that an enzyme is blocked, absent or working too fast. The map does not calculate pathway flow or select a supplement dose. Use the linked gene and nutrient lessons to understand the terms, then compare your actual findings with your clinician.

Names you may see

Transsulfuration · Transsulphuration · Sulfur pathway · Cysteine synthesis · Glutathione synthesis · CBS pathway · CTH pathway