Transsulfuration: from homocysteine to glutathione
An interactive walk through CBS, CTH, cysteine and glutathione, with connected folate and choline routes. Explore the genes, nutrients and Dr. Purser’s teaching one step at a time.
Updated Sep 23, 2026 · Educational reference
AN INTERACTIVE PATHWAY
Follow the connections.
Choose a step to see what happens, which genes participate, and where nutrients fit.
Explore a connected branch:
Transsulfuration steps
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Scroll across the map on a smaller screen, or use the step buttons below.
A simplified teaching map. Arrows show biochemical connections, not measured pathway activity or a prediction from your SNPs. Cofactors shown here are not dosing recommendations.
THE TEACHING CONNECTION
Follow sulfur from homocysteine toward cysteine, then see how cysteine contributes to glutathione.
Two directions from homocysteine
Homocysteine can be recycled to methionine through remethylation or enter transsulfuration toward cysteine. The folate/B12 route and the choline/betaine route shown above belong to remethylation. CBS and CTH form the central transsulfuration sequence. This distinction helps explain why folate, B12, B6 and amino acids are related but do not all perform the same job.
How Dr. Purser connects the pathway
Dr. Purser brings this pathway into his homocysteine, genetics and antioxidant teaching. He considers the inherited pathway picture alongside current homocysteine, nutrient findings, symptoms, medicines and tolerance. Cysteine availability, glutathione production, antioxidant use and recycling are connected questions rather than interchangeable test results.
Where the VARS Triad and MTHFR Daily fit
In Dr. Purser’s treatment framework, the VARS Triad—VARS Glutathione, VARS SOD and VARS Catalase—together with MTHFR Daily is a central consideration when homocysteine or cytokine issues are involved. He emphasizes VARS Glutathione as a foundational functional-support component across his genetic SNP teaching. The individual gene lesson explains how its pathway connects to that broader approach.
This describes the Purser treatment model, not proof that a product corrects a variant or treats every associated condition. Product choice, formulation, sequence and amount depend on the individual assessment, existing medicines, current findings and tolerance.
Reading the map alongside your results
A common SNP does not prove that an enzyme is blocked, absent or working too fast. The map does not calculate pathway flow or select a supplement dose. Use the linked gene and nutrient lessons to understand the terms, then compare your actual findings with your clinician.
Product and testing details from our practice and shop. Discuss what fits your needs with your clinician. Current labels, availability and pricing are shown on the linked pages.
High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy
🧬 High homocysteine isn’t just a heart problem—it’s a major player in fibromyalgia. If you’ve got fibro symptoms, there’s a good chance your transsulfuration pathway is broken—often due to 17 different SNPs or 12 key nutrient deficiencies. That means your body can’t detox properly or convert homocysteine into glutathione, leading to inflammation, pain, and fatigue. Don’t just chase labs—fix the root cause.
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Homocysteine- one of the most inflammatory substances in the body - can’t be broken down and converted into Glutathione if you have this deficiency: B6.
The transsulfuration pathway is broken if you don’t have sufficient B6 levels in your
Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho