Genetic variations in the MTHFR gene can affect the activity or function of the enzyme. The most well-known genetic variants are known as MTHFR C677T and MTHFR A1298C. These variations can lead to reduced enzyme activity, impacting the body's ability to process folate efficiently.

Methylation is a critical process for energy production in the body. It becomes impaired in individuals with methylation issues. This impairment prevents the adequate production of enzymes like MTHFR, which is crucial for methylating substances such as B12, pantothenic acid, magnesium, zinc, and copper. Additionally, it hampers detoxification processes and the production of glutathione, which is vital for eliminating toxins and heavy metals from the body. The significance of MTHFR-related diseases is evident in the high prevalence of two MTHFR genes among children with autism spectrum disorder, as they struggle to produce sufficient glutathione and are prone to heavy metal accumulation.

To those skeptical of these conditions, I present compelling laboratory evidence in my book, "The 85 Solution." Over the past 20 years since the Human Genome Project, we have gained much more knowledge about these conditions and their implications. However, our understanding is just scratching the surface, and there is an immense amount yet to be discovered in the vast sea of genetics. Younger physicians are urged to join me on this journey of understanding the genetics that will shape the future of medicine in the next century.

In "The 85 Solution," I delve into protocols for diagnosis, patient selection, and comprehensive treatment approaches. While these protocols are effective, they are continually evolving as our knowledge expands. The book serves as an ever-growing resource, and I will continue to update it as long as I live. I invite you to join me in exploring the depths of the Inland Sea, uncovering its secrets and learning more about MTHFR and the challenges faced by patients with methylation issues.

Make sure to check out my MTHFR Support supplements, both MTHFR RENEW and MTHFR ENDURE are available through physiciandesigned.com or Amazon.