THE PURSER WELLNESS LIBRARY

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A COURSE FOR YOUR CURIOSITYFatigue: asking better questions

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YouTubeAug 6, 2026

OVER-METHYLATION - Are Your B Vitamins Hurting You?

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Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

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