THE PURSER WELLNESS LIBRARY

Let’s explore Folate, serum — lab reference

Explore this topic as a step-by-step interactive map.MTHFR, the citric acid cycle & ATP
A COURSE FOR YOUR CURIOSITYMethylation & B vitamins

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YouTubeApr 8, 2026

Bio-identical Progesterone | Do’s and Don’ts

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This week Dan Purser MD and Jackson Larkin discuss the benefits and “pitfalls” of bio identical progesterone hormone replacement therapies. Progesterone, The Ultimate Women’s Feel Good Hormone, can be obtained in various forms. You want to make sure it is naturally derived from Wild Yam extract and that the compounded prescription version comes from Progesterone USP. This is the same version we use in our Femme Topical Progesterone serum, 20mg a dose versus 200mg prescriptions strength. Look for our new service of Telemed Consults and Compounded HRT’s in every state in the US! Coming Soon! Also check our Dr. Purser’s revamped Progesterone Book available now on Amazon. And if you happen to be in or post menopausal, check our Dr. Purser’s Hormone Health Course at danpursermd.com on the AMAZING Benefits of Progesterone for Women in Menopause.

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Gene referenceSep 23, 2026

DHFR

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DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.

Gene referenceSep 23, 2026

FOLR1

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FOLR1 encodes folate receptor alpha, which helps cells take up folate and has an important role in folate transport at the brain’s barriers. Blood folate and folate availability in the nervous system are not identical measurements.

Gene referenceSep 23, 2026

FOLR2

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FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

Gene referenceSep 23, 2026

GGH

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GGH encodes gamma-glutamyl hydrolase, which removes glutamate residues from folate compounds. This affects folate handling and helps explain why folate metabolism includes retention and processing as well as intake.

Gene referenceSep 23, 2026

MTHFS

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MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.

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