Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

MTHFS

MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Folinic acid has its own processing step

Folinic acid has its own processing step

MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate.

How Dr. Purser connects the pieces

Dr. Purser’s notes connect MTHFS with folate support and homocysteine. The useful lesson is that the form of folate matters and that several enzymes connect those forms. Discuss the actual product and response alongside B12 and homocysteine findings rather than assigning a folate form solely from rs6495446.

Where the VARS Triad and MTHFR Daily fit

In Dr. Purser’s treatment framework, the VARS Triad—VARS Glutathione, VARS SOD and VARS Catalase—together with MTHFR Daily is a central consideration when homocysteine or cytokine issues are involved. He emphasizes VARS Glutathione as a foundational functional-support component across his genetic SNP teaching. The individual gene lesson explains how its pathway connects to that broader approach.

This describes the Purser treatment model, not proof that a product corrects a variant or treats every associated condition. Product choice, formulation, sequence and amount depend on the individual assessment, existing medicines, current findings and tolerance.

A question to bring to your visit

How does my current folate form enter the pathway, and what evidence supports changing it?

Variant lookup

These teaching identifiers include regional research markers. Match them to your original laboratory report; listing alone does not establish clinical significance or a treatment need.

Names you may see

5-formyltetrahydrofolate cyclo-ligase