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Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Feeling tired all the time is often dismissed as stress, aging, or a busy schedule. But persistent fatigue can have many possible causes, including nutritional issues that may not be obvious from routine testing. A Cellular Micronutrient

What if your genes have been providing clues about your health your entire life? Most people spend years treating symptoms without ever asking why those symptoms exist in the first place. Genetic testing can provide valuable insight into

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

In this consultation review, Jackson sat down with longtime Purser Wellness patient Lois Schweigert to go over her latest intracellular micronutrient (CMA) test results. After years of dealing with fibromyalgia, pain, gut issues, and inconsistent energy, Lois has made remarkable progress. Her newest CMA shows ZERO deficiencies — her best results ever — and it perfectly matches how great she’s been feeling. We discuss: • Her consistent weight training and dramatically improved recovery (thanks to catalase!) • Key optimization tweaks: amino acids, omega-3s, chromium, inositol, and glutathione • Blood sugar stability • Sleep support and overnight recovery • How trauma & stress affect your nutrient levels • Why intracellular testing is so unique and powerful If you’re dealing with chronic symptoms, poor workout recovery, or just want to optimize your health, this conversation is packed with practical insights from real patient results. 👉 Ready to get your own CMA? Visit danpursermd.com or comment “CMA” below and we’ll send you info. #PurserWellness #Fibromyalgia #RootCauseHealth #CMATest #FunctionalMedicine This video is for educational purposes only and is based on Dr. Dan Purser’s protocols. Not medical advice. Always consult with your healthcare provider. Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🔬 What is VARS? Why the VARS Trio (Glutathione + SOD + Catalase) is a game-changer for inflammation, recovery & fibromyalgia. Jackson Larkin sits down with Lois Schweiger to break down Dr. Dan Purser MD’s VARS line — Validated, Absorbable, Reduced, and Stable antioxidants. Learn the science behind VARS Glutathione, VARS SOD (from deep-sea algae near volcanic vents), and the newest VARS Catalase (Nrf2 activator from seaweed). Discover: • How the VARS Triad works together in the mitochondria to fight oxidative stress and cytokines • Why Catalase dramatically improved post-workout recovery (especially leg day!) • Genetics, homocysteine, PEMT, and why many with fibro benefit from this protocol • The importance of CMA (intracellular) testing and when to retest • Real patient results, including severe inflammation cases Perfect for anyone dealing with chronic pain, inflammation, slow recovery, or looking for root-cause support. **June Anniversary Special**: $100 off Genetic + CMA testing — one order will be fully reimbursed! 👉 Learn more & shop VARS supplements: danpursermd.com #VARSGlutathione #Fibromyalgia #Antioxidants #ChronicInflammation #PurserWellness #Catalase #SOD Timestamps: 00:00 Intro & What Does VARS Mean? 01:45 The Science of the VARS Triad 12:00 Who Needs the Trio? 14:00 Catalase & Workout Recovery Stories 20:00 Genetics, Homocysteine & Testing Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Dan Purser MD interviews a patient with a brutal sarcoidosis case involving sky-high SIL2R cytokines, GI sarcoid, heart damage, and years of being dismissed by doctors. After spleen removal, repeated ER visits, and nitroglycerin dependence, he finally found answers. Learn how cytokine testing and the VARS Trio (Glutathione + SOD + Catalase) led to rapid improvement — going from bedridden fear to playing with grandkids in just weeks. This episode highlights the power of root-cause medicine for complex inflammatory conditions and offers hope for those who feel lost in the system. Perfect for listeners dealing with sarcoidosis, chronic inflammation, autoimmune issues, or cytokine-related symptoms. #Sarcoidosis #Cytokines #VARS #PurserWellness #ChronicIllnessRecovery Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🎉 June Anniversary Special at Purser Wellness! Join Dr. Dan Purser MD’s team — Chantel (Chicky), Denise Purser, and Lois Schweigert from End Fibro with Natural Options — for an honest, heartfelt conversation about living well with fibromyalgia. We share real-life stories of flares, recovery, and ongoing improvement using Dr. Purser’s protocol. From severe teenage fibromyalgia to thriving as grandmothers, we discuss how the VARS Trio (Glutathione, SOD, and the game-changing Catalase) helps manage inflammation, cytokines, and hydrogen peroxide — plus practical tips on low-copper diet, serving sizes, gym recovery, weight loss, and consistency over perfection. Topics covered: • How to handle fibro flares quickly (catalase + SOD stories) • The importance of intracellular testing (CMA) & genetics • Low-copper eating guidelines & why serving size matters • Building strength and muscle after years of pain • Why we keep improving year after year 🔥 June Special: $100 off Genetic Testing + CMA (deepest discount of the year). One lucky order will be fully reimbursed! 👉 Order tests & supplements: https://danpursermd.com (or link in comments) If you or someone you love deals with fibromyalgia, chronic pain, fatigue, or inflammation, this episode is full of hope and actionable advice. 💬 Drop your biggest takeaway or question below — we read every comment! Timestamps: 00:00 - Intro & June Anniversary Sale 02:30 - Real flare story & catalase rescue 06:00 - Long-term improvement on the protocol 12:00 - Starting slow with supplements (topical tips) 23:00 - Low-copper diet & food list tips 36:00 - Gym recovery & building muscle 50:00 - Weight loss benefits & consistency #Fibromyalgia #ChronicPain #NaturalWellness #PurserWellness #FibroRecovery #LowCopperDiet Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🙏 A Big Thank You to Our Purser Wellness Family! As a special thank you, we’re offering $50 off your next round of CMA testing or genetic testing through DanPurserMD.com! Use code: FBPurserWellness (You can apply it right on the website

What if your fatigue, inflammation, digestive issues, or chronic discomfort aren't random—and what if the answers have been available all along? Purser Wellness Coach Jackson Larkin explains why CMA testing is challenging conventional appr

Dr. Dan Purser here with an important update from Purser Wellness. Earlier this week we were deplatformed on a major platform right after discussing groundbreaking findings from our homocysteine research — particularly its connections to ASD, ADHD, cytokine issues, and inflammatory conditions like polymyalgia rheumatica (PMR). Despite losing access to our old page (and nearly 200,000 followers), we’re back stronger with a brand new official page! ✅ Follow our new official Facebook page here: https://www.facebook.com/purserwellness We’re keeping things focused and continuing our important work on root-cause wellness, intracellular nutrient deficiencies, genetics, glutathione/SOD balance, and more. ### Where to Stay Connected: - Substack (Daily research articles & in-depth content): https://substack.com/PurserWellness or https://danpursermd.substack.com - YouTube – Live streams and full recordings will continue here (plus TikTok, Instagram, and podcast platforms) Dr. Purser’s message is clear: We will not stop the research. “I’ll quit when I die… and maybe not even then.” If you’ve been following our work on homocysteine, MTHFR, cytokine problems, hormone optimization, and functional medicine protocols, please: - Like and follow the new Facebook page - Subscribe to Substack - Share this video with friends and patients who need this information Thank you for your incredible support during this transition. Your follows and shares help us keep delivering the cutting-edge research no one else is doing. 👉 New Facebook Page: https://www.facebook.com/purserwellness Purser Wellness Root-Cause Medicine • Genetics • Homocysteine Research danpursermd.com #DrDanPurser #PurserWellness #Homocysteine #FunctionalMedicine #RootCauseHealth #CytokineResearch #ASD #ADHD #MTHFR

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.