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That afternoon sugar craving may be telling you more than you think. Here’s how methylation, glucose, cellular energy and your genetics may fit into the bigger picture. https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube

You eat something sweet. Your energy shoots up. Then suddenly you are exhausted, foggy, irritable, and reaching for something else to get you through the day. That cycle deserves a closer look. MTHFR variants can influence folate meta

For years, fibromyalgia has largely been discussed through the lens of managing symptoms. Pain. Fatigue. Brain fog. Poor sleep. But researchers have also investigated oxidative stress and antioxidant defenses in people with fibromyalgia.

What if one of your body's most powerful defenses against oxidative stress is also one of the least talked about? Superoxide dismutase, better known as SOD, is an antioxidant enzyme that helps your body neutralize superoxide radicals befor

What if your homocysteine level is telling you more than you realize? When kidney function declines, homocysteine levels often rise because the kidneys play an important role in its metabolism and clearance. In people with chronic kidney d

What if fatty liver is not only about what you eat? Most people hear fatty liver and immediately think diet, weight, and alcohol. But your genetics and the way your body processes nutrients may also be part of a much bigger picture. One

Are your B vitamins making you feel worse instead of better? Methylated B vitamins can be incredibly helpful for energy, homocysteine metabolism, neurological health, and many essential processes. But the right nutrient can become the wron

Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Feeling tired all the time is often dismissed as stress, aging, or a busy schedule. But persistent fatigue can have many possible causes, including nutritional issues that may not be obvious from routine testing. A Cellular Micronutrient

The goal is not just getting a diagnosis. The goal is understanding what is happening in your body so you and your healthcare team can make informed decisions about your care. If you are tired of feeling dismissed or living with unexplain

Most people don't fail at weight loss because they lack motivation. They fail because they quit before consistency has a chance to work. We live in a world that promises overnight transformations, 30-day miracles, and quick fixes. But l

What if your recovery routine is just as important as your workout? Sore muscles, lingering fatigue, and slow recovery can make it harder to stay consistent in the gym. But what if supporting your body's recovery could help you get back