FOLH1 helps break down folate from food so it can be absorbed. This is different from the MTHFR step. Also called: Folate Hydrolase 1 Folate handling begins before remethylation Dr. Purser’s genetic chapters include FOLH1 in folate handling…
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What’s searchable?SHMT1 connects serine and glycine with folate chemistry. Also called: Serine Hydroxymethyltransferase 1 Where amino acids meet folate SHMT1 connects serine and glycine with folate pathways. That is one reason both nutrition and genetics can…
Encodes the reduced folate carrier, a protein involved in transporting folates into cells. Also called: RFC1, reduced folate carrier, folate transport Folate transport is part of the story Dr. Purser’s folate map includes transport as well …
MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate. Also called: Folinic acid has …
Follow the sulfur pathway from homocysteine toward cysteine and glutathione.
The folate cycle, methionine cycle, and transsulfuration pathway work together to move methyl groups and process homocysteine.
Explore folate, B12, B6, and homocysteine in a bone-health discussion.
BHMT helps recycle homocysteine into methionine using betaine. It is a different route from the folate and B12 pathway.
The homocysteine chapters include MTHFD1L in the wider folate-related genetic map.
Explore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.
Explore SERPINE1 / PAI-1, rs1799889, 4G/5G, fibrinolysis, hyperhomocysteinemia (HHcy), vascular health, and differences between approaches to clotting risk.
Dr. Purser’s subscriber report on PAI-1 4G/5G, homocysteine, and brain infarct risk. Read the report on Substack.
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