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High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a bloo…

Ever heard of MTHFR? No, it’s not a swear word—it’s a common genetic mutation that affects your body’s ability to methylate folate and produce energy from carbs. If you have the C677T or A1298C SNPs, it can lead to fatigue, brain fog, high

🚨 Can MTHFR Gene Mutations Be Dangerous? Yes. Here’s Why. 🚨 Did you know that MTHFR gene mutations can seriously impact your health? If you’re homozygous (double mutation) for multiple MTHFR SNPs—like C677T, A1298C, CBS, MTR, MTRR, and othe

💡 Are You Aware of Your Homocysteine Levels? 💡 Six key SNPs can cause dangerously high, fixed homocysteine levels. It’s crucial to understand this, especially if any of these SNPs are homozygous. If left unchecked, they can lead to serio…

Reminder to check out this post about the connections of MTHFR and Fibromyalgia. I like referring to fibromyalgia as a Copper Overload as that's what's really causing many of the issues. https://danpursermd.substack.com/p/cause-or-effect-

WHAT DOES A defective MTHFR gene structure do to you? 1. It causes a reduction in the production of the critical MTHFR enzyme, causing methylation to occur at only 40% of a healthy body’s capacity, or even as much as 70% of its capacity

WHAT DOES A defective MTHFR gene structure do to you? 1. It causes a reduction in the production of the critical MTHFR enzyme, causing methylation to occur at only 40% of a healthy body’s capacity, or even as much as 70% of its capacity

Chapter 1: Homocysteine- A Historical and Clinical Perspective Homocysteine: how the story developed Why this matters Understand why homocysteine became a health topic and why lowering a blood number is not the same as preventing disease.…

Chapter 2: Understanding Homocysteine- Causes, Implications, and Management Understanding homocysteine and its pathways Why this matters See the two main routes for processing homocysteine and what may affect a blood result. How the piec…

Chapter 12: Homocysteine - A Central Driver of Elevated D-Dimer, CRP, hsCRP, and Inflammatory Markers Homocysteine, D-dimer and inflammatory markers Why this matters See what homocysteine, D-dimer, and CRP each measure. How the pieces co…

Chapter 13: Two Landmark Articles -- The Role of Homocysteine and Glutathione in Monocyte-Mediated Inflammatory Responses Two studies behind the homocysteine–glutathione model Why this matters Compare studies of homocysteine and glutathio…

Chapter 14: Homocysteine Elevation, Inflammatory Markers, Transsulfuration Pathway Disruption, and Toxicant Exposures in Genetic Hyperhomocysteinemia Homocysteine and environmental exposures Why this matters Separate questions about toxin…