…ieces
The teaching links the gut story with IL23R, PEMT and folate-related pathways: immune signaling, membranes/bile and nutrient handling can all enter the same conversation. Those connections do not make an IBS label, Crohn’s disease or …
Dr.
Also called: Methylenetetrahydrofolate Dehydrogenase 1
Folate has several working forms
Dr. Purser includes MTHFD1 among genes involved in folate interconversion. The lesson is that folate participates in several reactions and exists in…
… why a methylation discussion should include B12 as well as folate, and why adding more folate alone does not answer every question.
How Dr. Purser connects the pieces
MTRR helps keep this system working by supporting reactivation of methio…
…ies context; it is not a measurement of how much B12 is available in your tissues.
A question to bring to your visit
Which current findings show whether this pathway needs attention now, and are several products duplicating B12 or folate?
R…
…ion. The route toward cysteine is called transsulfuration.
Folate and B12 help with one recycling route. Betaine, which can come from choline, helps with another. CBS and CTH carry out the two core steps toward cysteine. These nutrients an…
…the intrinsic-factor–B12 complex.
Connections in the Purser reference
The reference groups this subject with: B12 absorption, Intrinsic factor receptor activity, Methylation, Folate metabolism. These are teaching connections, not a diagnosi…
…gle-nucleotide changes reduce the enzyme methylenetetrahydrofolate reductase activity by 30–70%, impairing the conversion of folate into its active form (5-methyltetrahydrofolate). The downstream result? Impaired methylation, elevated plasm…
… kidney or blood pressure issues.
Homocysteine isn’t just a lab number — it’s a toxic byproduct that drives inflammation through cytokines like MCP-1 and IL-8, damaging blood vessels and disrupting hormones.
Dr. Purser’s research found up t…
…ep Dive Highlights:
Neuropathy Relief: Using VARS Revive & Serum X can not only alleviate pain but also promote nerve healing. These Super Antioxidants combat oxidative stress, a major culprit behind neuropathy.
Fibromyalgia & Metal Overl…
…els look great.
2. The defective enzyme doesn’t break down folate vitamins properly (of which folic acid is the precursor to), which can cause high homocysteine levels (hyperhomocysteinemia), which causes vascular inflammation which in tur…
… homocysteine.
Follow the connections
The chapter connects folate handling, methylation, vitamin B12 recycling and sulfur-amino-acid metabolism. Use the gene names as routes into the gene reference library. The exact variant identifier and…
Do you know what causes chronic fatigue? Dr. Purser explains the top causes of Chronic Fatigue Syndrome (CFS) and shares what steps to take to feel normal again. Discover why CFS is a symptom of underlying conditions and what the treatment of underlying causes of CFS includes. Dr. Purser dispels the myth of medication deficiency related to CFS symptoms. Discover the relationship of nutritional deficiencies, hormone imbalance, and poorly understood genetic causes from MTHFR deficiency to fatigue. Learn what contributes to fatigue when the absorption of Vitamin B12, folate, pantothenate, and oth
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