Understanding the Genetic Basis and Implications of PEMT Variants
In the descriptionA subscriber post from Purser Wellness on Substack, covering genetics and methylation, gut and digestion.
THE PURSER WELLNESS LIBRARY
4 chapters, at your pace
80 discoveries for your curiosity
What’s searchable?A subscriber post from Purser Wellness on Substack, covering genetics and methylation, gut and digestion.
A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, genetics and methylation.
A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.
A post from Purser Wellness on Substack, covering genetics and methylation, gut and digestion, mind, mood, and sleep.
A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.
Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.
Read matching passageHow Broken Methylation, High Homocysteine, and Depleted Glutathione Are Driving the Rise Since the 1980s
And Why Your Methylation, Homocysteine, and Glutathione Pathways Are the Missing Link
Dr. Purser shares his clinical perspective on homocysteine, methylation, and inflammatory patterns.
A post from Purser Wellness on Substack, covering genetics and methylation, mind, mood, and sleep.
Not all genetic tests are created equal. Many only scratch the surface, while the best panels look at hundreds of SNPs that impact methylation, detox, hormones, and nutrient absorption. For real results, you need a test that’s private, comprehensive, and clinically useful—like the ones we recommend in practice that help guide targeted treatment plans.
This week Dr. Purser shares his findings and treatment protocols for Interstitial Cystitis. He classifies this disease as the worst version of fibromyalgia, but covers best ways to treat it. Try a low copper diet, understand your underlying methylation genetics, and use beneficial supplements. Contact us at (801) 796-7667 or info@danpursermd.com for help. Subscribe to stay up-to-date with new content!
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