Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
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Homocysteine is nasty — but here’s the truth no one tells you. It doesn’t kill you directly — it triggers white blood cells to release IL-8 and MCP-1, causing inflammation, kidney failure, heart attacks, and strokes. Most doctors don’t even check it anymore, thinking there’s no fix. But there is. Whether from 17 genetic SNPs or 12 vitamin deficiencies (like B6 or B12), you can address it by supporting your body’s ability to convert homocysteine into glutathione.
…nsformation pathway. There are however for normal people 12 vitamin deficiencies. If you have any one of those like serene or um or um you go back and look at that list, there's several of them on there. Um and there are so there are 12 of …
…nsformation pathway. There are however for normal people 12 vitamin deficiencies. If you have any one of those like serarene or um or um you go back and look at that list, there's several of them on there. Um and there are so there are 12 o…
…ttle six-year-old kids. Um and so you counsel them on their vitamins. Yep. On their vitamins. Nutrition. So we'll see how it goes. This is Jackson talking. Yeah. Yeah. He's a licensed nutrition counselor. So accredited or whatever. What do …
…ne that's the breakdown of all of 50 different nutrients uh vitamins, minerals, and and amino acids that you may be deficient in. And so this is the key page of our of our testing results that we focus a lot on in our appointments. These ex…
…l asked me about. Will it help POTS? Not necessarily. But a vitamin panel we do always helps the pots. say or vitamin B we never not clear up pots cases if it is a some kind of injury I won't say the first word case um the spike protein is …
…k about tonight, Chantel? I'm gonna let you choose. I think vitamins. Everybody wants to know about vitamins. They do? Yeah. I think that'd be that's okay. Good. We'll we'll do that. Kind of boring, but okay. We can make it exciting. Um lik…
…e in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical obse…
…t about what you eat.
Nutrition matters.
Folate matters.
Vitamin B12 matters.
Vitamin B6 matters.
Lifestyle matters.
Genetics may matter too.
So why are we waiting until disease appears before asking what our biology has been telling…
… DNA variation that affects how your body processes folate (vitamin B9).
The most common variants, C677T and A1298C, can reduce your ability to make ATP, your body’s main energy source. This can lead to low energy, poor detox, and mood chal…
…while transsulfuration moves it toward cysteine. Folate and B12 appear in the recycling discussion; B6 appears in the transsulfuration discussion. These names describe connected reactions rather than a list of supplements everyone needs. Th…
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