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…es infections, kidney inflammation, and complement-mediated disease. The word “homozygous” alone does not show whether a finding reduces function, increases activity, or is a common benign variant. Bring these questions to your visit Ask f…

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… the connection Ulcerative colitis is an inflammatory bowel disease affecting the colon. Diagnosis and disease activity require a combination of symptoms, examination, and testing. Follow the pathway Dr. Purser explains TNF-alpha, IL-12, I…

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… skin-cell growth. Some people also have inflammatory joint disease. Follow the pathway Dr. Purser explains the IL-23/Th17 pathway and distinguishes IL-17A and IL-17F from IL-17C produced by skin cells. This helps explain the feedback betw…

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…response and one associated with connective-tissue or other disease. Bring these questions to your visit Ask whether examination, nailfold assessment, antibodies, or other tests would help distinguish the type. Persistent sores or marked p…

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…s inflammation inside the eye. The cause may involve immune disease, infection, or another process, so an eye examination is essential. Follow the pathway Dr. Purser follows IL-12 and the Th1 response into IFN-gamma, TNF-alpha, macrophage …

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… is an autoimmune condition that can affect several organs. Disease activity is assessed through symptoms, examination, and multiple tests. Follow the pathway Dr. Purser discusses type I interferons, BAFF/BLyS, IL-17, and other cytokines i…

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…. Understand the connection F9 encodes clotting factor IX. Disease-causing variants can be involved in hemophilia B, a bleeding disorder. F9 is on the X chromosome, which changes how inheritance is described. Follow the pathway Dr. Purser…

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