IL17A encodes interleukin-17A, a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23.
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What’s searchable?IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.
IL18R1 encodes a component of the receptor for IL-18. It works with an accessory component, IL18RAP, to support IL-18 signaling.
IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response.
IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP.
IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting.
IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses.
IL2RA encodes the alpha chain of the interleukin-2 receptor, also called CD25. It is involved in immune activation and regulatory T-cell biology; a soluble receptor measurement is distinct from a DNA result.
IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and promote type 2 immune responses. It belongs in a different functional group from chemokines that recruit cells.
IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather than representing all allergic biology by itself.
IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions.
IL6R encodes the interleukin-6 receptor. Membrane-bound and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood sample.
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