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Everyone talks about MTHFR. But what if that is only one piece of the puzzle? MTHFR helps process folate, while MTR helps recycle homocysteine back into methionine with the help of vitamin B12. Two genes. Different roles. One interco

Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

Homocysteine is nasty — but here’s the truth no one tells you. It doesn’t kill you directly — it triggers white blood cells to release IL-8 and MCP-1, causing inflammation, kidney failure, heart attacks, and strokes. Most doctors don’t even check it anymore, thinking there’s no fix. But there is. Whether from 17 genetic SNPs or 12 vitamin deficiencies (like B6 or B12), you can address it by supporting your body’s ability to convert homocysteine into glutathione.

Dr. Purser talks about a meta-analysis where correlations are drawn between Crohn's disease, ulcerative colitis, inflammatory bowel diseases, and B12 folate deficiencies. However, it is unclear how each are directly related. PubMed Study: https://pubmed.ncbi.nlm.nih.gov/28406440/ Contact us at (801) 796-7667 or info@danpursermd.com for help. Subscribe to stay up-to-date with new content!

Explore the relationship of vitamin deficiency and neuropathy, a painful and disabling condition. Learn how a SpectraCell Comprehensive Nutritional Panel can help reveal intracellular deficiencies. Explore the relationship of how genetic diseases, such as MTHFR, relate to neuropathy. Discover how Methyl B12 (Methylcobalamin) may treat neuropathy. Contact us at (801) 796-7667 or info@danpursermd.com for help. Check back often for the newest updates!

If you are low or think you're low in Iron, you HAVE to try Vitamin B12 and Vitamin C to boost your levels. Seeking Health has a great Methyl Free B vitamin complex, and our VARS Vitamin C from PhysicianDesigned.com is your best option for FUNCTIONAL vitamin C. Boost your levels and always remember you can get a CMA Intracellular Test if you want to see your other levels. Reach to my office with any questions. 801-796-7667 Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Many patients with POTS (Postural Orthostatic Tachycardia Syndrome) are told it’s “just bad luck,” but often it’s linked to key nutrient deficiencies. Low levels of B12, folate, copper, and glutathione can impair blood vessel and nervous sy

Doctors have spent decades trying to lower homocysteine with B6, B12, folate, or $12,000/month injections. But it’s not the homocysteine doing the damage—it’s the IL-8 and MCP-1 cytokines it releases. That’s where glutathione (especially VARS or Glutaryl) changes the game. We’ve seen cytokine levels drop to zero—and symptoms vanish. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

🧬 After reviewing over 78,000 tests, Dr. Purser sees the same deficiencies over and over again—especially in fibro patients: Copper & zinc (often imbalanced): Glutathione, B6, B12 & folate, Glutamine, boron, molybdenum, And don’t forget mag

🧬 After reviewing over 78,000 tests, Dr. Purser sees the same deficiencies over and over again—especially in fibro patients: Copper & zinc (often imbalanced): Glutathione, B6, B12 & folate, Glutamine, boron, molybdenum, And don’t forget magnesium—a major cause of leg cramps and muscle pain. If you’re dealing with fibro, fatigue, or chronic pain, this list is where to start. The good news? It’s all fixable. Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

Been put on psych meds but still not feeling better? 😟 The real issue might not be a need for Prozac or amitriptyline—it could be a vitamin deficiency like low B12, folate, CoQ10, or lithium. 🧬 Fix the deficiencies first with a CMA with Red