How are MTHFR and Fibromyalgia so closely connected? Methylation pathways and the conversion of Homocysteine to Glutathione. These are critical for humans but certain genetic factors make them much less efficient. Help is on the way.
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A term in this discussion
Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
A term in this discussion
Learn the vocabulary before trying to interpret a pathway.
More on Homocysteine: follow the connections
How Elevated Homocysteine, Impaired Methylation, and Glutathione Deficiency May Be Driving PCOS, Chronic Pain, Brain Fog, Stroke Risk, and Detox Failure — and Why Genetic Testing WILL Change the Way https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube
More on Homocysteine: follow the connections
High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy
