How Elevated Homocysteine, Impaired Methylation, and Glutathione Deficiency May Be Driving PCOS, Chronic Pain, Brain Fog, Stroke Risk, and Detox Failure — and Why Genetic Testing WILL Change the Way
Homoyine is interesting. It causes a lot of problems or indicates a lot of problems. Really, if your homoyine is high and I've said this before, it really indicates a big um uh interruption in your transforation pathway, meaning it's never worked. You
can't detox. You can't convert homocyine to glutathione. That does a lot of really weird things to your bodies. This is what I'm finding. PCOS and homocyine all the PCOS pa patients I've treated lately strictly anecdotal probably 12 in
the last since I kind of started considering this seem to have a bad homocyine problem so that's why they always have so much inflammation he hurt all over um and become infertile and stuff like that typical um homoyine
hyperhomocyine has it's called hscy hcy Sorry. Um and um and um it makes it really uncomfortable for him. Also, all the fibromyalgia patients I've treated
recently in office and stuff or over Zoom. Um it's really a a nutritional problem more than anything seem to have a homoyine problem too, which is weird. Um but it isn't because they can't detox. they can't get rid of heavy
metals like copper very easily, excess copper. So I can understand why they have their fibromyalgia because um if you're IL8 and MCP1 are really high causes a lot of muscle inflammation and pain and you can't detox properly. So um
maybe get the genetics report um u or maybe get our genetic test. I designed it to look at all 17 of the snips that could cause um hyperhomocyinemmia. I don't think there's another test out there that'll do it. If you have even
one of those snips be homozygous, that's a that's a disruption of your of your transforation pathway and you can't get rid of toxins. You can't convert homoyine to glutathione which helps you get rid of toxins and it causes a lot of muscle
inflammation and pain. Just a thought. um us you out there that um that check that you can check a homoyine level but it's better to check the genetic level because if you're malnourished you'll have a low homocyine level even if you have the genetics for it if you're not
malnourished um then your homoyine level will be normal or and normal for you might be quite high and very painful but um it also um they quit doing that starving people to death in 2002 the Lord they're home assisting thank odd
because it was bad. People were dying much more quickly from that being malnourished than they were from the homoyine problem. But you don't want to have to deal with either. Also, um if you have a high homocyine or genetically should have a high homocyine level and
it's not high, then uh check a uh a CMA with a redux that we use. Really handy test for that. We'll figure it out. Just some thoughts. Uh watch for my book. It's going to be called something something homo sustaining something something Dan Pererd
don't know. I have an agent in New York so we'll see how that goes. It's Dr. Dan Perer. Thanks. Well, did you want to keep talking for a minute? If anyone has any questions, they can definitely ask. Oh, really? Yeah. But I I had So, we're doing a video. We're doing it live, not Yeah. I really Okay. I got like one minute.
Yeah. Okay. Real quick with with this homoyine treatment, we definitely get everyone on glutathione just to help. Well, lowers the ILA. It's not a homoyine treatment. Your homoyine is going to be fixed in place no matter what you do unless you're malnourished. And then just like I said in 2002, they
quit trying that trick because people were dying more quickly from the malnourishment. Being malnourished, even one or two vitamins, severe deficiency is a real problem for your health and immune system, everything else. So, yeah. Um, but the glutathione
lowers the IL8 and the MCP-1. There's lots of papers that support that. Tons of research on it. Just no one know knew that we had the world's only oral patented glutathione and ours works quite well. We have several hundred labs now that show that it lowers iolate to
zero or close to it. Yeah. Lowers it to normal and people have a high one. So we have before and after. So we're going to be putting that. That's the last page we got to work on. Jackson. Yeah. Um but we will be putting that in there. Uh so yeah, can't detox without glue.
Oh, you hit a lot of glutathione and detox. Yeah. So, what's interesting, you were talking about PCOS, the connections to homoyine issues, transforation issues, as well as MTHFR and methylation issues. It's all interconnected. Homocyine
SIS that cause hyperhomocytoia are strictly methylation s of them. Yep. Yeah. They're all under the MTH4 banner. And if you're homozygous C677T or homoyg 1298C, you're guaranteed to have a high homoyine level unless you're
malnourished. Yeah. And that's just falsely suppressed. Yep. So that's why exactly what we do in our clinic is the perfect treatment for it. Look at those methylation issues. Um balance out the deficiencies of glutathione. And
I literally could do this all day long. Yeah. I um pretty much. Yeah. I foresee in the near future there'll be clinics that strictly deal with homo assisting problems. Wow. So, um, and because there's a way to deal with it, but it's it's a little bit of a tightroppe ballerina dance trying
to work your way through all the issues. Yeah. Yeah. So, but almost number one cause of kidney failure and it causes those invisible heart attacks and strokes that just knock people over. Yeah. And they're dead before they hit the ground. Crazy. Crazy. Crazy. Okay. Any questions? Uh, no. There's no questions in there.
But they hate me. No. No, no, there's people watching. Hey you guys. Um, you should ask me how can you get the number one Well, I'm pretty much number one in the universe for number one in the USA. The number one the number one MD for by popular vote really Google reviewed all all
social media reviews, fivestar reviewed MD in the USA on,200 plus five star reviews. Um, and uh I didn't even know I had that many. I don't even know what a review is really of 66. Why would I Why
would I know what a review is? I've never left one. Maybe a couple on Amazon or something I like, but I don't even know. That was easy. They make it easy. So, um anyway, yeah, just a thought. Should ask questions. Okay, we'll roll. I had to go see a patient. Yep. Back to patient. See you guys. See
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High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy
Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho
— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav
A fast look at the genetic quirks I came across this week, from odd inherited traits to the ones that can seriously affect health. Clear, curious, and a little alarming.