Sex hormone-binding globulin (SHBG) — lab reference
In the reference guideEstrogen, thyroid, liver disease, insulin resistance, age, and medications affect SHBG.
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What’s searchable?Estrogen, thyroid, liver disease, insulin resistance, age, and medications affect SHBG.
Interpret with testosterone or estradiol, FSH, cycle phase, and pituitary context.
Interpret with age, ovarian status, testosterone/estradiol, and pituitary context.
Often calculated. Consider SPEP/IFE for unexplained abnormalities.
Calculated; interpret component values.
Binding abnormalities and severe illness may affect some free-hormone assays.
Affected by thyroid-binding globulin, pregnancy, estrogen, and medications.
Interpret with iron, transferrin saturation, and ferritin.
Ovarian reserve marker, not egg quality. PCOS and hormonal treatments may affect interpretation.
Pulsatile secretion makes random GH difficult to interpret; stimulation/suppression testing may be needed.
Interpret with calcium, phosphorus, magnesium, vitamin D, and kidney function.
Morning collection preferred for men. Method and age matter; confirm unexpected low values.
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