Let’s explore “CCL2”

This report overview covers monocyte chemoattractant protein-1, CCR2, monocytes, macrophages, and immune-cell recruitment into tissues.

…ency. Topics: homocysteine, monocytes, IL-8, CXCL8, MCP-1, CCL2, NF-kB, oxidative stress

…ged over time? Topics: kidney disease, IL-8, CXCL8, MCP-1, CCL2, renal fibrosis, microvascular injury, ESRD, TGF-beta

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

Most people have never heard of homocysteine, yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model, which explains why homo

PURSER WELLNESSGlutathione and Your Ability To Detox?A conversation with Dr. Purser

Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine storms. That’s why VARS Glutathione is such a breakthrough: it’s reduced, functional, and proven to lower harmful cytokines like IL-8 and MCP-1, giving your body the detox power it needs. After 15 years of research and real patient results, it’s the only oral glutathione that actually works where it matters—inside your cells.

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation. This is not fringe theory. It is the clinical reality I have

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

PURSER WELLNESSHomocysteine is the Secret AssasinA conversation with Dr. Purser

Homocysteine is nasty — but here’s the truth no one tells you. It doesn’t kill you directly — it triggers white blood cells to release IL-8 and MCP-1, causing inflammation, kidney failure, heart attacks, and strokes. Most doctors don’t even check it anymore, thinking there’s no fix. But there is. Whether from 17 genetic SNPs or 12 vitamin deficiencies (like B6 or B12), you can address it by supporting your body’s ability to convert homocysteine into glutathione.

PURSER WELLNESSThe True Potential of Glutathione?A conversation with Dr. Purser

Struggling with inflammation, high cytokines, or conditions like psoriasis, kidney disease, or chronic fatigue? The root cause could be elevated interleukins like IL-8 and MCP-1, often triggered by high homocysteine levels. The most powerful natural solution we’ve found?

PURSER WELLNESSIs there a way to relieve hypertension naturally?A conversation with Dr. Purser

Struggling with high blood pressure that just won’t budge—even with multiple meds? It might be due to genetic issues causing high homocysteine , which can stiffen your arteries through IL-8 and MCP-1 cytokines.

A post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.