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IL23R encodes part of the receptor that receives IL-23 signals. This connects the gene to the maintenance of Th17-related immune responses, which differ from the Th2 patterns discussed in allergy. Also called: IL-23R, Interleukin 23 Recepto…

Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.

HMGB1 normally has functions inside the cell nucleus. When released outside cells in particular settings, it can act as a damage-associated molecular pattern, or DAMP, participating in inflammatory signaling. Also called: A cellular protei…

IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather than representing all allergic biology by itself. Also calle…

Explore Toll-like receptor 4, lipopolysaccharide (LPS), HMGB1, innate immune sensing, and related inflammatory pathways. Understand the connection TLR4 helps recognize bacterial lipopolysaccharide, or LPS, with assistance from CD14 and MD-…

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

Iodine Benefits!! Learn all about it on my substack Thyroid Health: Iodine is a key component of thyroid hormones, thyroxine (T4) and triiodothyronine (T3). These hormones regulate the body's metabolism, energy production, and other essent

Do you know what causes chronic fatigue? Dr. Purser explains the top causes of Chronic Fatigue Syndrome (CFS) and shares what steps to take to feel normal again. Discover why CFS is a symptom of underlying conditions and what the treatment of underlying causes of CFS includes. Dr. Purser dispels the myth of medication deficiency related to CFS symptoms. Discover the relationship of nutritional deficiencies, hormone imbalance, and poorly understood genetic causes from MTHFR deficiency to fatigue. Learn what contributes to fatigue when the absorption of Vitamin B12, folate, pantothenate, and oth

Kidney disease has many possible causes. Understand the connection Kidney disease has many possible causes. Inflammation can participate in injury, but glucose, blood pressure, infection, obstruction, medicines, and other processes also ne…

Understand the difference between primary and secondary Raynaud’s in this report.

This TNF promoter variant appears in Dr. Purser’s discussion of inflammatory signaling.

This immune-mediated condition can affect the optic nerves and spinal cord.