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Dr. Purser’s subscriber report on COL5A1. Open the original publication to read the report with your Substack access.

🚨 Why do you keep craving sugar and crashing even when you’re trying to eat healthy? If you have an MTHFR variant, it’s likely NOT just willpower — it’s a methylation & energy production issue at the cellular level. In our latest video, we

What if brain fog isn't a normal part of getting older? What if it's your body's way of telling you something is wrong? Too many people have accepted forgetfulness, poor focus, mental fatigue, and difficulty concentrating as part of every

What if one tiny genetic variation could quietly influence how your body detoxifies, processes nutrients, and even supports your mental health—and most people have never heard of it? MTHFR isn’t just another health buzzword. It’s a conversa

Did you know that one of the most challenging symptoms of MTHFR can impact your daily life in ways you might not expect? Let’s dive into what it is, how to recognize it, and what you can do to start feeling better. Have you experienced this

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.

Not all genetic tests are created equal. Many only scratch the surface, while the best panels look at hundreds of SNPs that impact methylation, detox, hormones, and nutrient absorption. For real results, you need a test that’s private, comprehensive, and clinically useful—like the ones we recommend in practice that help guide targeted treatment plans.

High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.

This week Dr. Purser explains the many wonderful benefits of testosterone for women! It's not an oxymoron! Learn the best ways to increase female libido and how to deal with dryness. Make sure to tune in next week for a great discussion on MTHFR Genetic Transcription Errors. Contact us at (801) 796-7667 or info@danpursermd.com for help. Subscribe to stay up-to-date with new content!

Dr. Purser answers questions regarding estradiol, estrogens, and other hormones. Explore the relationship of estradiol to estrogen and learn which hormones are most effective at different stages of menopause: premenopause, perimenopause, and postmenopause. Discover the relationship of conjugated equine estrogens (such as Premarin) as a risk factor in breast cancer. Learn about hormone replacement therapy's effect on bone density, osteoporosis, fibromyalgia, coagulation, MTHFR, and other medical issues. Find out which foods, supplements, and essential oils can be of benefit to you. Contact us a

Every woman with PCOS I’ve ever tested has a homocysteine problem... That’s what Dr. Dan Purser says — and it might explain why so many women with PCOS struggle with pain, inflammation, fatigue, and even kidney or blood pressure issues. Hom