MTHFD1 helps move folate between forms used for different jobs in the body. Also called: Methylenetetrahydrofolate Dehydrogenase 1 Folate has several working forms Dr. Purser includes MTHFD1 among genes involved in folate interconversion. T…
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What’s searchable?…ps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism. Also called: Methionine Synthase Reductase Keeping the remethylation system working Dr. Purser teaches MTRR alongside MTR becaus…
Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine. Also called: Follow the branches around homocysteine Homocysteine sits at a junction in the pathway. Dr. Purser’s teaching follows ho…
…nt team. Also called: An antioxidant team with different jobs Dr. Purser teaches redox defense as a connected team. SOD handles superoxide and produces hydrogen peroxide. Catalase and glutathione peroxidases help handle peroxides. Glutathi…
… recruit monocytes through the CCR2 receptor. Monocytes can become macrophages, cells that remove debris and participate in inflammation. Follow the pathway Dr. Purser follows the CCL2–CCR2 pathway through blood-vessel, kidney, and metabol…
…pports defense and repair; persistent recruitment can contribute to inflammation. Follow the pathway Dr. Purser discusses macrophage activity, osteoclasts that break down bone, and inflammatory joint damage. His teaching also connects CCL3…
Explore membrane and soluble CD14, lipopolysaccharide (LPS), TLR4, and innate immune activation. Understand the connection CD14 helps the immune system recognize lipopolysaccharide, or LPS, from the outer surface of certain bacteria. It ap…
Explore CD40L, antigen-presenting cells, antibody class switching, and autoimmunity. Understand the connection CD40 is a receptor involved in communication between immune cells. Its partner, CD40L, helps activated T cells communicate with …
…AP is an accessory part of the IL-18 receptor. IL18R1 helps bind the cytokine; IL18RAP helps the receptor complex send its signal inside the cell. Follow the pathway Dr. Purser follows this receptor complex through MyD88 and NF-κB signalin…
…h17 cells, IL-21R, JAK/STAT terminology, and cellular redox balance. Understand the connection IL-21 is produced by immune cells including follicular helper T cells and Th17 cells. It influences B cells, antibody responses, and other parts…
Explore Toll-like receptor 2, microbial and damage signals, TLR1, TLR6, and MyD88 signaling. Understand the connection TLR2 is a pattern-recognition receptor that helps immune cells detect components of microbes and damaged tissue. It ofte…
Explore high mobility group box 1, damage-associated molecular patterns (DAMPs), TLR4, RAGE, and cellular stress. Understand the connection HMGB1 normally helps organize DNA inside a cell. When it is released outside injured or stressed ce…
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