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NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor. Also called: Mineralocorticoid Receptor / Nuclear…

PSEN2 encodes a presenilin protein that participates in gamma-secretase, a protein-processing complex. Some pathogenic variants can cause familial Alzheimer’s disease; a listed common marker is not equivalent to that diagnosis. Also called:…

SOD2 works in mitochondria as part of the body’s antioxidant defenses. Also called: Superoxide Dismutase 2 Superoxide defense in its own setting Dr. Purser teaches SOD as one member of an antioxidant team. SOD2 works in mitochondria and use…

…mmune disease or another cause of inflammation, and the genotype does not determine a measured TNF level. More from the teaching: Understanding inflammatory amplification Dr. Purser discusses TNF-alpha as an inflammatory messenger in the co…

Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine. Also called: Follow the branches around homocysteine Homocysteine sits at a junction in the pathway. Dr. Purser’s teaching follows ho…

…atically evidence that detoxification is working. How these signals may connect Outlive Your Toxic Genetics links homocysteine, reduced glutathione availability, oxidative signaling and inflammatory messenger release in a proposed feedback …

…okine cluster. The useful lesson is overlapping recruitment signals rather than a unique disease prediction from one marker. Closely related genes and nearby variants need careful naming and mapping. A question to bring to your visit Has th…

…. It participates in a recruitment network that includes CCL2, CXCL8 and related chemokines. Also called: MIP-1 beta and overlapping recruitment signals CCL4 encodes MIP-1 beta, a chemokine involved in attracting immune cells. It participa…

…ship to CCL3 and CCL4 helps explain why several recruitment signals can overlap during an inflammatory episode. A CCL5 marker cannot identify the trigger on its own. A question to bring to your visit Which symptoms, exposures or diagnoses g…

IL13 encodes interleukin-13, a cytokine involved in Th2 immune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same signal. Also called: Allergic signaling and tissue responses …

…ther Dr. Purser’s panel places IL-16 among pro-inflammatory signals. The teaching value is to connect recruitment with the larger inflammatory picture instead of assigning a diagnosis to a numbered cytokine. Current symptoms, examination an…

… my symptoms and eosinophil findings support an allergic or eosinophilic pattern? Variant IDs in the teaching reference: rs2069812, rs334809 Also called: IL-5, Interleukin 5 Where the VARS Triad and MTHFR Daily fit If you are exploring homo…