Everyone talks about MTHFR.
But what if that is only one piece of the puzzle?
MTHFR helps process folate, while MTR helps recycle homocysteine back into methionine with the help of vitamin B12.
Two genes.
Different roles.
One interco
… MTHFR, SHMT1 and SLC19A1 and asks about current methylated-vitamin exposure. The practical question is how the whole folate/B12 pattern fits the person’s findings and tolerance, rather than treating every named gene as a separate supplemen…
…together instead of treating a folate result as an isolated vitamin issue.
How Dr. Purser connects the pieces
His wider map connects methylation with downstream sulfur handling and glutathione production. Learning the connection helps you d…
TCN2 appears in Dr.
Also called: Transcobalamin II
B12 must be carried as well as consumed
TCN2 appears in Dr. Purser’s homocysteine and methylation map because it concerns the transport of B12. The teaching distinction is between eating or…
…ute toward cysteine is called transsulfuration.
Folate and B12 help with one recycling route. Betaine, which can come from choline, helps with another. CBS and CTH carry out the two core steps toward cysteine. These nutrients and enzymes w…
This report overview covers folate, vitamin B9, one-carbon metabolism, anemia, homocysteine, SLC19A1, and the report’s comparisons of folate forms and transport pathways.
Can the B vitamins you are taking to support energy and methylation eventually make you feel worse?
In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as:
• 5-MTHF or methylfolate
• Methylcobalamin
• Trimethylglycine, also called TMG
• Multiple overlapping methylation formulas
Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.”
These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered.
In this video, we discuss:
• Why methylation is essential
• How methyl-donor supplements support the body
• Why the right vitamin can become the wrong dose
• Ingredients to look for on your supplement labels
• Why some people may need lower doses or non-methylated forms
• How genetics and intracellular nutrient testing can guide a more personalized plan
At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual.
Learn more or schedule with Purser Wellness:
https://danpursermd.com
Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional.
#Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness
Follow Dr. Purser!
Info: http://www.DanPurserMD.com
Supplements: https://www.PhysicianDesigned.com
Books: https://www.amazon.com/-/e/B00BIKSGVQ
Facebook: https://www.facebook.com/danpursermd
Facebook: https://www.facebook.com/PhysicianDesigned
Twitter: https://twitter.com/realdanpursermd
YouTube: https://www.youtube.com/danpursermd
Instagram: https://www.instagram.com/danpurser.md
Pinterest: https://www.pinterest.com/danpursermd
Could an overlooked lab marker be providing valuable insight into your health?
Understanding your homocysteine level may help you and your healthcare provider identify opportunities to support cardiovascular health, healthy methylation, an
Most people think Vitamin B3 is just another vitamin.
They're wrong.
Niacin (Vitamin B3) plays a critical role in energy production, metabolism, cellular repair, and overall wellness—yet many people have no idea how important it really is
What if one overlooked lab marker is telling you more about your health than you realize?
Most people have never heard of homocysteine.
Yet when homocysteine levels are elevated, it may signal that critical pathways involving methylation,
👋 Ever stared at your lab results and thought, “What am I even looking at here?”
We hear that all the time with our CMA with Redox testing. Patients get TWO pages of results, and without a clear explanation it can feel overwhelming.
In th
Most people don’t realize how much vitamin deficiencies can quietly affect how they feel day to day. Low energy, brain fog, weakened immunity—these can all be signs your body isn’t getting what it needs.
Understanding why these deficiencies
Best match puts all-term matches before partial matches and related reading. Identical social posts and matching long titles across other sources are grouped when access is the same. Search covers published titles, descriptions, available article text, report overviews, and the full text of the nutrient, gene and learning-essential reference pages. Books, uploaded chapters and downloads-page reports are searchable through selected editorial guides and topic names; the original files and full book text are not published. Full Drive reports are not copied into search. Substack subscriber titles and public summaries are included; full subscriber content opens on Substack. Video transcripts are added when available.