Let’s explore “transsulfuration”

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering genetics and methylation, inflammation and antioxidants.

This chapter connects genetic variation with the sulfur pathway that appears throughout Dr. Purser’s redox teaching.

This report overview covers the author’s homocysteine teaching notes on transsulfuration, methylation, glutathione, genetic variants, cytokines, and the connections proposed in the collection.

PURSER WELLNESSToxins Are Especially Bad For YOU!A conversation with Dr. Purser

Why do some people in the same family get destroyed by black mold… while others are completely fine? Why do two kids develop autism while their siblings are completely normal? Dr. Dan Purser explains the hidden genetic issue behind both: a homocysteine problem that disrupts the transsulfuration pathway — the pathway responsible for making ~90% of your glutathione. Without enough glutathione, your body simply cannot clear toxins. Mold, heavy metals, environmental chemicals… they stay stuck. This is why some people get chronically ill and others don’t, even when living in the exact same house. In this episode we cover: How a genetic disruption in the transsulfuration pathway causes low glutathione Why most “glutathione” products on Amazon do nothing The only two patented forms that actually work Real cases of black mold toxicity and autism improvement Why checking genetics is more important than just checking a homocysteine level This is root-cause medicine — not symptom chasing. Learn more: Website: https://danpursermd.com Two Glutathione: https://twoglutathione.com Substack: https://danpursermd.substack.com Office: (801) 796-7667 Email: info@danpursermd.com #Homocysteine #Glutathione #BlackMold #Autism #Detox #RootCauseMedicine #PurserWellness #Genetics

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

PURSER WELLNESSAUTSIM - What is a potential ROOT CAUSE of Autism? Can it be helped?A conversation with Dr. Purser

What I see again and again is an inability to detox caused by failures in the Transsulfuration Pathway. This is your pathway that converts homocysteine to glutathione. If you have MTHFR or 16 other Gene SNPs, you will have problems with this pathway.

PURSER WELLNESSDefeat inflammation with the one simple molecule!A conversation with Dr. Purser

Homocysteine is bad for you, but it’s a critical part of the transsulfuration pathway. You don’t make glutathione wothout it, but when your levels of homocysteine get too high, it becomes majorly problematic for you.

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

… involving: methylation folate metabolism redox balance the transsulfuration pathway glutathione production When certain variants occur in a homozygous state, they can significantly increase a person’s baseline homocysteine levels. This may…

…ethylation, Methionine processing, Homocysteine regulation, Transsulfuration. These are teaching connections, not a diagnosis or a measured effect in your body. Understanding a result A gene name is not a test result. Interpretation needs t…

…steine remethylation, Methylation, Homocysteine regulation, Transsulfuration. These are teaching connections, not a diagnosis or a measured effect in your body. Understanding a result A gene name is not a test result. Interpretation needs t…