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MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialize

If you have MTHFR gene mutations like C677T or A1298C, you’re likely low in more than just B12 and folate. 🧬 We consistently see deficiencies in B6 (pyridoxine), glutamine, glutathione, and sometimes methionine—all key players in energy, de

You know tou have MTHFR, you even know what version you have, C677T or A2198C, but now what? What can you do about it? Worry not, there is an elegant solution for you. My MTHFR Renew and Endure products are for you. If you’re just starting

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.

Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.

High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.

Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u

Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your e

Ever heard of MTHFR? No, it’s not a swear word—it’s a common genetic mutation that affects your body’s ability to methylate folate and produce energy from carbs. If you have the C677T or A1298C SNPs, it can lead to fatigue, brain fog, high

🚨 Can MTHFR Gene Mutations Be Dangerous? Yes. Here’s Why. 🚨 Did you know that MTHFR gene mutations can seriously impact your health? If you’re homozygous (double mutation) for multiple MTHFR SNPs—like C677T, A1298C, CBS, MTR, MTRR, and othe

…tic snip. There's two variants that we like to look at. The C677T and the A1298C. If you've gotten your genetic testing done, hey, let us know which one do you have. Are you hetererozygous, homozygous? I'm always super curious to know about…