THE PURSER WELLNESS LIBRARY
5 chapters, at your pace
61 discoveries for your curiosity
What’s searchable?MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.
Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.
High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.
Dr. Purser explains the diagnosis and treatment of MTHFR (methylenteterahydrofolate reductase enzyme deficiency disease). Learn the genetic component of this illness (such as C677T or A1298C) and how it affects the body's inability of methylation to convert carbohydrates into ATP (Adenosine Triphosphate). Discover how the complex enzyme pathways of the Krebs cycle and citric acid cycle convert carbohydrate molecules into ATP molecules in the mitochondria. Explore the relationship of MTHFR to vitamin and hormone deficiencies while understanding how vitamin supplements can replace key missing (u
…tion carries at least one MTHFR polymorphism (most commonly C677T or A1298C). These single-nucleotide changes reduce the enzyme methylenetetrahydrofolate reductase activity by 30–70%, impairing the conversion of folate into its active form …
… and possibly you. Learn the meaning of MTHFR Heterozygous, C677T, MTHFR Homozygous, A1298C, folate depression. As you find out how to use a MTHFR Protocol for each disease, use natural folate, methylfolate dosage, and MTHFR vitamins. Explo…
…his contains FOLINIC ACID and not the Quatrafolate that the C677T errors need. Great stuff. Try the PLUS with the MTHFR SUPPORT. MTHFR SUPPORT is available now from us with our Physician Designed label (me). Try it if you have MTHFR — BEST …
A subscriber episode exploring questions about MTHFR, nutrient status, and daily energy. Read the public introduction and continue on Substack.
Dan Purser MD and Jackson Larkin discuss the connections they consider between sugar cravings, cellular energy, and methylation.
A Guide by the World’s Leading Homocysteine Expert
CoQ10 is an important nutrient that improves hypothyroidism and metabolism naturally. Explore how CoQ10 can help you with your energy levels and feel younger!
Most people have never heard of homocysteine, yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model, which explains why homo
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