CBS helps move homocysteine into the pathway that supplies building blocks for glutathione.
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What’s searchable?CHDH helps convert choline toward betaine, a nutrient involved in the homocysteine pathway.
The homocysteine chapters include MTHFD1L in the wider folate-related genetic map.
Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.
Helps maintain the activity of methionine synthase, connecting B12-related chemistry with homocysteine metabolism.
VDR encodes the vitamin D receptor, which helps regulate gene activity in response to active vitamin D. A receptor variant does not by itself mean receptors are absent or that the blood vitamin D level is low.
ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme important to bone and tooth mineralization and vitamin B6 metabolism. Persistently low alkaline phosphatase can deserve a different evaluation from a general nutrient deficiency.
Good questions deserve a deeper conversation. Purser Wellness Explore is a new space to follow yours - videos, articles, and guided journeys with me. Start with MTHFR, cytokines, homocysteine, gut health… or whatever thread you’re holding
Explore folate, vitamin B9, one-carbon metabolism, anemia, homocysteine, SLC19A1, and differences between folate forms and transport pathways.
Explore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.
Explore the reduced folate carrier (RFC1), rs3788200, rs1051266, intracellular folate, homocysteine, and folinic acid and methylfolate.
How Broken Methylation, High Homocysteine, and Depleted Glutathione Are Driving the Rise Since the 1980s
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