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Explore Toll-like receptor 4, lipopolysaccharide (LPS), HMGB1, innate immune sensing, and related inflammatory pathways.

Omega-3 contain PUFAs (at least the better ones do). If you have an Omega-3, or any omega, deficiency, it will causes disruption of the insulin recceptor function and again its transport of glucose into the cell. This causes diabetes. The

…deficiency? Will effect your thyroid production and thyroid receptor function -- weight loss will not happen very effectively. (This is the most common intracellular deficiency I see, by the way...) Selenium deficiency? Same as zinc. Will …

…s these pathways with targeted therapies such as interferon-receptor and B-cell signaling treatments, while separately considering oxidative stress and nutrient status. Bring these questions to your visit Ask which findings show active dis…

… stuck. Follow the pathway Dr. Purser discusses IL-4/IL-13 signaling, eosinophils, and the IL-4 receptor alpha target of dupilumab. He considers oxidative stress alongside approaches such as dietary evaluation and prescribed treatment. Br…

…nderstand the connection Dr. Purser explores IL-23 and Th17 signaling in fatty liver disease and inflammatory liver conditions. Older terms NAFLD and NASH appear alongside the newer terms MASLD and MASH. Follow the pathway This teaching fo…

…ss, and treatment research. Understand the connection IL-6 signaling intersects with metabolism, insulin resistance, and inflammatory responses in the liver. Fatty liver disease can progress to inflammation and scarring in some people. Fo…

…also called MCP-1, helps recruit monocytes through the CCR2 receptor. Monocytes can become macrophages, cells that remove debris and participate in inflammation. Follow the pathway Dr. Purser follows the CCL2–CCR2 pathway through blood-ves…

…ing, and autoimmunity. Understand the connection CD40 is a receptor involved in communication between immune cells. Its partner, CD40L, helps activated T cells communicate with B cells and other cells that present material to the immune sy…

…rser connects NLRP3 activation, IL-18, and interferon-gamma signaling. IL-18 works through a receptor system that includes IL18R1 and IL18RAP, linking an initial danger response with downstream immune-cell activity. Bring these questions t…

…r discusses tissue injury, local inflammation, and the IL-1 receptor response. This teaching also connects immune alarms with oxidative stress and explains why blocking a signaling pathway differs from supporting antioxidant defenses. Brin…

…ive immunity. Follow the pathway Dr. Purser explains IL-21 receptor signaling through JAK and STAT proteins, including STAT3. He discusses how ongoing immune activation can affect tissues and why treatment questions depend on a confirmed c…