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Gene referenceSep 23, 2026
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IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP. Also called: An inflammatory signal that connects to int…

Gene referenceSep 23, 2026
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IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather than representing all allergic biology by itself. Also calle…

Gene referenceSep 23, 2026
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MTHFS encodes an enzyme that converts 5-formyltetrahydrofolate into 5,10-methenyltetrahydrofolate. This places it in folate interconversion; it is not another name for MTHFR or a direct maker of methylfolate. Also called: Folinic acid has …

Gene referenceSep 23, 2026
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RAD50 encodes a DNA-repair protein. The surrounding genomic region also contains regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene. Also called…

Learning essentialsSep 23, 2026
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See how homocysteine connects to cysteine and glutathione. Follow seven simple steps, explore the side routes, and tap a word or building block to learn more. Also called: Transsulfuration, Transsulphuration, Sulfur pathway, Cysteine synthe…

Health BlogSep 18, 2026
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Your local doctor will likely tell you that MTHFR testing and taking an MTHFR Daily supplement is a waste of money. They might even claim it isn't a real medical issue. After 15 years of hearing this pap, I can tell you they are flat-out wr…

Report teachingSep 16, 2026
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Explore multiple sclerosis (MS), central nervous system inflammation, myelin, symptoms, and related immune signals. Understand the connection Multiple sclerosis involves immune-mediated injury to myelin and other nervous-system structures.…

Report teachingAug 16, 2026
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Explore eotaxin-1, CCR3, eosinophils, allergy, and respiratory and neurological conditions. Understand the connection CCL11, also called eotaxin-1, guides eosinophils toward tissues by signaling through CCR3. Eosinophils are immune cells i…

Report teachingAug 16, 2026
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Explore interleukin-4, Th2 cells, immunoglobulin E (IgE), and allergic and atopic conditions. Understand the connection IL-4 helps organize type 2 immune responses and supports antibody switching toward IgE. This makes it relevant to aller…

Report teachingAug 16, 2026
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…plore interleukin-6, C-reactive protein (CRP), the acute-phase response, rheumatoid arthritis, and related health conditions. Understand the connection IL-6 is an immune messenger that participates in inflammation, infection responses, and…

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