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DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.

Encodes an enzyme involved in fatty-acid metabolism.

Encodes an enzyme involved in fatty-acid metabolism.

G6PC2 encodes a glucose-6-phosphatase-related protein expressed in pancreatic islet cells. Common variation is associated with differences in fasting glucose regulation; it is not the insulin receptor.

Explore HbA1c, red blood cell turnover, hemoglobin variants, blood loss, hypoglycemia, and factors that may affect a low A1C result.

Explore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.

Too many people are told to manage the pain, accept the fatigue, and learn to live around their symptoms. But accepting your diagnosis does not mean you have to stop searching for ways to better support your body. The Purser Wellness Fibr

The MTHFR Sugar Crash Cycle. The answers to the answers to the problems no one else has ever been able to give you. Find the support and help you've been looking for at PurserWellness.com

Dan and Jackson discuss methylated B vitamins, the term overmethylation, and questions to ask when your response to a supplement changes.

🌾 Why has gluten intolerance exploded since the 1970s? It’s not just the bread. In my latest blog I lay out the clear timeline: Roundup (glyphosate) was introduced in 1974… and the rise in celiac disease and gluten sensitivity has tracked

Scurvy may sound like a relic of the past, but this physician is still diagnosing it today. Nutrition gaps, restrictive diets, and heavily processed foods can leave people with bleeding gums, chronic fatigue, unexplained pain, bruising, and

Insulin resistance starts long before high blood sugar shows up — and it often begins with deficiencies in zinc, B12, chromium, selenium, and omega-3s. Fix the deficiencies, and you can often restore