Encyclopedia

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants, mind, mood, and sleep.

How Broken Methylation, High Homocysteine, and Depleted Glutathione Are Driving the Rise Since the 1980s

🌾 Why has gluten intolerance exploded since the 1970s? It’s not just the bread. In my latest blog I lay out the clear timeline: Roundup (glyphosate) was introduced in 1974… and the rise in celiac disease and gluten sensitivity has tracked

🧬 MTHFR Mutations, High Homocysteine & Autoimmune Disease: The Hidden Root Cause Most Doctors Miss For decades, patients with RA, lupus, MS, Hashimoto’s, and fibromyalgia chase symptom relief with meds that never fix the underlying fire. A

A episode from Purser Wellness on Substack, covering mind, mood, and sleep.

You’ve been told you’re fine. Your labs look “normal.” Your doctor shrugs. Maybe you need more sleep. Less stress. A different mindset. And yet—you wake up exhausted. You drag through the day. You collapse at night, only to do it all over a

From Brain Fog to Burnout: The Hidden Deficiencies Your Bloodwork Misses. By Dan Purser MD

— A Guide by the World’s Leading Homocysteine Expert For more than four decades as a practicing physician, I have watched thousands of patients cycle through conventional autoimmune treatments that address symptoms but never touch the fire underneath. Rheumatoid arthritis flares, lupus rashes, multiple sclerosis relapses, Hashimoto’s thyroiditis, fibromyalgia pain—these are not random. They share a common, often overlooked biochemical pathway: MTHFR mutations leading to elevated homocysteine that supercharges autoimmune inflammation . This is not fringe theory. It is the clinical reality I hav

What testing do you NEED to get done to truly heal the ROOT of your symptoms? Whether it IBS, GERD, POTS, PCOS, Low Testosterone, Menopause, Fatigue, Anxiety, Depression, you need to get to the very bottom of your symptoms. Genetic Testing

What testing do you NEED to get done to truly heal the ROOT of your symptoms? Whether it IBS, GERD, POTS, PCOS, Low Testosterone, Menopause, Fatigue, Anxiety, Depression, you need to get to the very bottom of your symptoms. Genetic Testing

Inflammation, Brain Fog, Gut Issues and More

Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho