IL12B encodes the p40 subunit shared by IL-12 and IL-23. This makes it an intersection between immune pathways rather than a stand-alone measure of one cytokine.
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What’s searchable?IL13 encodes interleukin-13, a cytokine involved in Th2 immune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same signal.
IL15 encodes a cytokine involved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA.
IL16 encodes interleukin-16, a cytokine involved in attracting and influencing immune cells, including CD4-expressing cells. Its recruitment role helps separate it from other numbered interleukins.
IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.
IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP.
IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting.
IL4 encodes interleukin-4, a cytokine involved in Th2 immune responses and antibody class switching, including pathways related to IgE. It operates alongside IL-5 and IL-13 rather than representing all allergic biology by itself.
IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions.
IL6R encodes the interleukin-6 receptor. Membrane-bound and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood sample.
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