IL10 encodes interleukin-10, a cytokine that can limit inflammatory responses and help prevent excessive immune-mediated tissue damage. Immune balance includes resolving a response as well as starting one.
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What’s searchable?IL12B encodes the p40 subunit shared by IL-12 and IL-23. This makes it an intersection between immune pathways rather than a stand-alone measure of one cytokine.
IL15 encodes a cytokine involved in the survival and activity of immune cells, including natural killer cells and memory CD8 T cells. Its receptor system includes IL15RA.
IL17A encodes interleukin-17A, a cytokine involved in defense at tissue barriers and inflammatory signaling. It belongs to the Th17 pathway, which is supported by signals including IL-23.
IL18 encodes interleukin-18, a cytokine that can promote interferon-gamma responses in the appropriate immune context. Its receptor includes components encoded by IL18R1 and IL18RAP.
IL1B encodes interleukin-1 beta, a cytokine involved in inflammatory responses and fever. Its production and activation are regulated processes, not simply an on/off consequence of having a common SNP.
IL22 encodes a cytokine that acts on tissues such as epithelial barriers. It can support barrier defense and repair, while its effects depend on the tissue and inflammatory setting.
IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses.
IL5 encodes interleukin-5, a cytokine important to eosinophil growth, survival and activation. Eosinophils are involved in selected allergic and other inflammatory conditions.
IL6R encodes the interleukin-6 receptor. Membrane-bound and soluble receptor pathways help explain why IL-6 biology involves more than the amount of cytokine in a single blood sample.
Explore skin-barrier symptoms, acantholysis, cytokine networks, and redox management.
Dr. Purser’s subscriber report on IL-5, cytokine genetics, and the topics discussed in his homozygous IL5 variant report.
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