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…abolism, mitochondrial energy production, nutrients, sleep, stress, and genetics. MTHFR is one major piece of that bigger picture. Variants such as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself.…

…ins how repeated immune-cell recruitment can sustain tissue inflammation. His teaching connects this pathway with allergic inflammation and discusses the relationship between immune signaling and oxidative stress. Bring these questions to …

…efense and repair; persistent recruitment can contribute to inflammation. Follow the pathway Dr. Purser discusses macrophage activity, osteoclasts that break down bone, and inflammatory joint damage. His teaching also connects CCL3 signali…

…L4 with T-cell and macrophage recruitment and the way local inflammation can continue after the initial trigger. He discusses oxidative stress and antioxidant defenses as part of that ongoing response. Bring these questions to your visit A…

… nitric oxide synthase, endothelial function, and oxidative stress. DDAH1 is not a cytokine, even when it appears in a discussion of vascular inflammation. Bring these questions to your visit Ask whether ADMA, blood pressure, kidney functi…

…ponse with macrophage activation, antigen presentation, and inflammation. He discusses the interaction of IFN-γ with TNF-alpha, barrier tissues, and oxidative stress rather than treating any one cytokine as the whole explanation. Bring the…

…T-cell and macrophage activity and the relationship between inflammation and oxidative stress. A genotype needs to be considered alongside measured findings and symptoms. Bring these questions to your visit Ask which result is being discus…

… is an alarm signal stored in some barrier cells. Injury or stress can release it, helping alert the immune system that tissue needs attention. Follow the pathway Dr. Purser discusses the ST2 receptor, type 2 immune responses, and signals …

…connection IL-6 is an immune messenger that participates in inflammation, infection responses, and tissue repair. It can signal through membrane-bound or soluble IL-6 receptors and the gp130 signaling protein. Follow the pathway Dr. Purser…

…and pyroptosis. Understand the connection NLRP3 is an intracellular danger sensor, rather than a circulating cytokine. It can assemble an inflammasome, a protein complex involved in activating inflammatory responses. Follow the pathway Dr…

…ariants (especially MTHFR and related SNPs) can disrupt the body’s ability to produce glutathione, leading to impaired detoxification, chronic inflammation, and developmental challenges. We walk through the science behind the transsulfurat…

…dy struggling (especially if you have MTHFR variants), your body can’t clear toxins as well. That leads to more inflammation, leaky gut, and yes — gluten becoming a bigger problem for more people. If you or someone you love deals with fati…