Explore SERPINE1 / PAI-1, rs1799889, 4G/5G, fibrinolysis, hyperhomocysteinemia (HHcy), vascular health, and differences between approaches to clotting risk.
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What’s searchable?Dr. Purser’s subscriber report on PAI-1 4G/5G, homocysteine, and brain infarct risk. Read the report on Substack.
SERPINE1 makes PAI-1, a protein involved in breaking down blood clots. You may also see PAI4G used for this pathway.
Follow Dr. Purser’s teaching on folate, B12, sulfur pathways and antioxidant support around homocysteine.
See how homocysteine connects to cysteine and glutathione. Follow seven simple steps, explore the side routes, and tap a word or building block to learn more.
No universal wellness target. Ask your clinician to read this result with B12, folate, B6, kidney, thyroid, genetics, and medications.
Makes an enzyme that helps produce a form of folate used in the processing of homocysteine. Common variants are different from rare variants that cause severe MTHFR deficiency.
Most people have never heard of homocysteine , yet this small molecule may hold the key to understanding inflammation, cardiovascular disease, neurological problems, and many chronic conditions. For decades, homocysteine was viewed as a toxic substance in the blood. Doctors were taught that lowering it with B-vitamins might reduce heart disease risk. But research results were inconsistent, leaving many physicians unsure whether homocysteine truly mattered. New research and clinical observations are changing that view. We introduce a new framework called the Purser Model , which explains why ho
Explore Dr. Purser’s connection between methylation and purine pathways.
Follow Dr. Purser’s discussion of folate metabolism and inflammation.
Homocysteine rarely gets the attention of cholesterol, blood sugar, or blood pressure. It should. When homocysteine becomes elevated, it has been associated with cardiovascular disease, stroke, cognitive decline, blood clots, and other he
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Instagram listingExplore transsulfuration, methylation, glutathione, genetic variants, cytokines, and possible connections.
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