If you’ve been told you have the MTRR gene mutation and struggle with fatigue, depression, or high homocysteine, this might be your missing link. MTRR mutations can impair your body’s ability to make SAMe (S-adenosyl methionine)—a critical compound for mood, energy, and methylation. For many of my patients, supplementing with SAMe (like Nature’s Trove 200mg) has been a life-changing game-changer—just start slow (one capsule/day) and monitor how you feel. It won’t work for everyone, but when it does, the results can be dramatic.