How to produce more ATP with MTHFR? How to stop the unending fatigue that comes from low ATP caused by MTHFR? You have to get to the root, the intracellular levels of key vitamins and minerals that support the folate methylation cycle. Fill the holes left by your genetics and you “magically” atart to feel better. This is a workaround to your genetics, bur one that can be sustained throughout your life.