Let’s explore “vitamin D”

DAOA is the gene symbol used for D-Amino Acid Oxidase Activator. This page connects its terminology with the topics in the Purser Wellness teaching library.

Makes the methionine synthase enzyme, which uses vitamin B12 in the conversion of homocysteine to methionine.

PLD3 is the gene symbol used for Phospholipase D Family Member 3. This page connects its terminology with the topics in the Purser Wellness teaching library.

VKORC1 is the gene symbol used for Vitamin K Epoxide Reductase Complex Subunit 1. This page connects its terminology with the topics in the Purser Wellness teaching library.

This report overview covers D-amino acid oxidase activator (DAOA / G72), rs2391191, D-serine, NMDA receptors, glutamate signaling, and the psychiatric and cognitive associations discussed in the source.

PURSER WELLNESSOVER-METHYLATION - Are Your B Vitamins Hurting You?A conversation with Dr. Purser

Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSDr. Purser in the Bahamas - How is MTHFR Support Different From MTHFR Support Plus?A conversation with Dr. Purser

This video is coming from the Bahamas! Dr. Purser talks about the difference between MTHFR Support and MTHFR Support Plus. He explains how to use both together effectively to help your vitamin deficiencies!

PURSER WELLNESSCope with Homocysteine Like a Pro!A conversation with Dr. Purser

High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cy

PURSER WELLNESSHow To Know If You Have High Homocysteine?A conversation with Dr. Purser

High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a blood test can measure homocysteine directly, while a CMA with Redox uncovers the vitamin deficiencies driving it. For genetic causes, the DRP Genetics panel screens 15–16 of the 17 known SNPs that can cause permanently high homocysteine. If your levels are fixed by genetics, reduced glutathione and targeted B vitamins (like MTHFR Daily) are key to balancing the

PURSER WELLNESSThe Struggle of HomocysteineA conversation with Dr. Purser

High homocysteine? It’s not the number—it’s the cytokines it triggers (like IL-8) that cause strokes, kidney failure & inflammation. We found 17 gene SNPs + 12 vitamin deficiencies that drive it—and VARS Glutathione helps shut it down.

PURSER WELLNESSHomocysteine is the Secret AssasinA conversation with Dr. Purser

Homocysteine is nasty — but here’s the truth no one tells you. It doesn’t kill you directly — it triggers white blood cells to release IL-8 and MCP-1, causing inflammation, kidney failure, heart attacks, and strokes. Most doctors don’t even check it anymore, thinking there’s no fix. But there is. Whether from 17 genetic SNPs or 12 vitamin deficiencies (like B6 or B12), you can address it by supporting your body’s ability to convert homocysteine into glutathione.

PURSER WELLNESSRemove inflammation by combatting High HomocysteineA conversation with Dr. Purser

High homocysteine levels can lead to inflammation, joint and muscle pain, and even shifting pain throughout the body. It’s also linked to birth defects and chronic kidney failure, and can raise blood pressure. Six genetic SNPs (like MTR, MTRR, and CBS) and MTHFR mutations (like C677T) can prevent homocysteine from converting into glutathione, which is essential for keeping inflammation in check. Plus, 12 vitamin deficiencies may temporarily raise homocysteine levels, so addressing these deficiencies is key.