Let’s explore “Transsulfuration: from homocysteine to glutathione”

DHFR helps reduce folic acid and dihydrofolate to tetrahydrofolate-related forms used in cellular metabolism. This is one part of the folate system, distinct from MTHFR and folate transport into cells.

ESR1 encodes estrogen receptor alpha, which helps cells respond to estrogen. Receptor signaling is different from the amount of estrogen measured in blood.

FOLR2 encodes folate receptor beta, a folate-binding protein expressed in particular cell types, including subsets of immune cells. It is distinct from the FOLR1 receptor and the SLC19A1 reduced folate carrier.

NOS3 encodes endothelial nitric oxide synthase, which helps blood vessels generate nitric oxide, a signal involved in vascular relaxation. This pathway is distinct from a blood pressure measurement or a diagnosis of vascular disease.

NR3C2 encodes the mineralocorticoid receptor, which responds to hormones such as aldosterone and helps regulate salt and fluid balance. It is distinct from the NR3C1 glucocorticoid receptor.

ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme important to bone and tooth mineralization and vitamin B6 metabolism. Persistently low alkaline phosphatase can deserve a different evaluation from a general nutrient deficiency.

Good questions deserve a deeper conversation. Purser Wellness Explore is a new space to follow yours - videos, articles, and guided journeys with me. Start with MTHFR, cytokines, homocysteine, gut health… or whatever thread you’re holding

Explore folate, vitamin B9, one-carbon metabolism, anemia, homocysteine, SLC19A1, and differences between folate forms and transport pathways.

Explore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.

What if the antioxidant conversation is bigger than just one supplement? Glutathione. SOD. Catalase. Three powerful parts of the body's antioxidant defense network. Three different roles. One bigger conversation about cellular wellnes

What if your diagnosis does not get the final word? From days dominated by fibromyalgia pain and exhaustion to building strength, pursuing fitness, and reaching levels of performance that once felt impossible. That kind of journey changes

Why support just one part of your antioxidant defense system when you can think bigger? Meet the VARS TRIAD. VARS SOD. VARS Glutathione. VARS Catalase. Three separate products. Three important antioxidant focused approaches. One po