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… two best-known MTHFR variants. Putting the pieces together Follow the connection to folate availability and the cellular processes that use one-carbon units. The pathway provides context, but it cannot tell you from the gene name alone whe…

…ahydrofolate Reductase, C677T, A1298C, folate, homocysteine Follow the pathway beyond MTHFR Dr. Purser teaches MTHFR within a larger folate and homocysteine pathway. MTHFR contributes to production of the folate form used in remethylation; …

…ys. That is one reason both nutrition and genetics can come up in a folate conversation. Neither a gene result nor a folate number tells the whole story alone. Putting the pieces together His wider map connects methylation with downstream s…

…places CETP in his cholesterol and cardiovascular teaching. Follow the connection through measured lipids, family history and overall cardiovascular risk. A SNP does not by itself select a CETP inhibitor or establish that HDL is low; medica…

… subunit encoded by IL12B, it forms a cytokine involved in supporting Th17 responses. Also called: The p19 component of IL-23 IL23A encodes the p19 subunit of interleukin-23. Together with the p40 subunit encoded by IL12B, it forms a cytok…

…2 immune responses. It belongs in a different functional group from chemokines that recruit cells. Also called: An alarmin in allergic signaling IL33 encodes interleukin-33, a signal that can act as an alarmin during tissue stress and prom…

… Watch a video. Read an article. Take a guided course. Look up a gene or an unfamiliar term without losing your place. You don’t need to know all the vocabulary before you begin. That’s part of why we built this. My goal is to help you un…

Encodes cubilin, part of a receptor system involved in uptake of the intrinsic-factor–B12 complex. Also called: Cubilin Start here Encodes cubilin, part of a receptor system involved in uptake of the intrinsic-factor–B12 complex. How this g…

… AOC1, the gene involved in digestive histamine breakdown. Follow the pathway Dr. Purser discusses rs2391191, also described as Arg30Lys, alongside glutamate signaling and research on mood and cognition. D-serine helps NMDA receptors respo…

…C1 gene and calcium handling are central to the condition. Follow the pathway Dr. Purser connects acantholysis, friction, heat, infection, inflammatory cytokines, and oxidative stress. He discusses the antioxidant triad as an adjunctive qu…

… This can prevent that section from moving stool normally. Follow the pathway Dr. Purser discusses enteric nervous-system development and genes involved in that process. This developmental disorder is different from an acquired nutrient de…

…high-expression variants. Understand the connection IL-15 supports natural killer cells and certain T cells, including memory CD8+ T cells. Immune memory can protect against infection while also contributing to persistent immune activity i…