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CXCL8 is the gene for IL-8, a chemokine involved in recruiting and activating neutrophils. IL-8 is the protein nickname; CXCL8 is the gene name a DNA report may use.

IL18RAP encodes an accessory protein in the IL-18 receptor complex. The receptor needs coordinated components to translate an extracellular signal into a cellular response.

RAD50 encodes a DNA-repair protein. The surrounding genomic region also contains regulatory elements relevant to the nearby IL4, IL5 and IL13 cluster, so a locus association can concern more than the coding function of one gene.

TNFSF10 encodes TRAIL, a signaling protein involved in regulated cell death through particular receptors. It is a different member of the TNF-related signaling family from TNF itself.

Explore rs2236225, rs1076991, folate-dependent one-carbon metabolism, nucleotide synthesis, homocysteine, and double homozygosity.

Explore monocyte chemoattractant protein-1, CCR2, monocytes, macrophages, and immune-cell recruitment into tissues.

Explore macrophage inflammatory protein-1 alpha, CCR1, CCR5, and the recruitment of myeloid cells and lymphocytes.

Explore macrophage inflammatory protein-1 beta, CCR5, T cells, natural killer cells, and monocytes.

Explore interleukin-18 receptor accessory protein, IL18R1, MyD88, and mucosal and systemic inflammation.

Explore interleukin-6, C-reactive protein (CRP), the acute-phase response, rheumatoid arthritis, and related health conditions.

What if your food isn't as nutritious as you think? Calories are easy to count. Protein is easy to track. But the real story lies in the vitamins, minerals, antioxidants, and trace nutrients your body depends on every single day. Most

MTHFR & The Never-Ending Sugar Crash Cycle: Why You’re Always Tired & Craving Sweets If you have an MTHFR variant (C677T or A1298C), you may constantly battle fatigue, sugar cravings, and energy crashes — even when you’re “doing everything right.” In this video, we break down exactly why this happens: How MTHFR/methylation issues impair ATP (energy) production at the cellular level Why your body desperately reaches for quick glucose The vicious cycle of blood sugar spikes → insulin crashes → more cravings & fat storage The downstream effects on antioxidants, DNA repair, and overall energy How to finally break the cycle: Targeted supplementation that fills methylation “holes” (what we learned from 15–20k intracellular tests) Why our MTHFR Daily multivitamin was specifically formulated for this The power of CMA intracellular testing Intermittent fasting (12–16 hrs) Fasted cardio (even just a brisk walk) High-protein, real-food diet with minimal processed sugars If you’re tired of the sugar rollercoaster and want stable energy, this is for you. Links: Read the full Substack article → https://danpursermd.substack.com/p/the-mthfrsugar-craving-cycle Get your CMA intracellular testing & genetics done → Call our office or visit danpursermd.com Shop MTHFR Daily → https://physiciandesigned.com/products/mthfr-daily Have an MTHFR variant? Drop your genotype (heterozygous/homozygous) in the comments — I’m always curious! #MTHFR #SugarCravings #Methylation #ChronicFatigue #Energy #PurserWellness #FunctionalMedicine #IntermittentFasting Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd