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…soluble IL-6 receptors and the gp130 signaling protein. Follow the pathway Dr. Purser discusses classic signaling, trans-signaling, JAK/STAT3, and the liver’s production of C-reactive protein. He also connects homocysteine and oxidative st…

…a chemokine, a signal that guides immune-cell movement. Follow the pathway Dr. Purser connects IL-8 with inflammatory activity in barrier tissues, blood vessels, and lungs. He discusses monocyte activation, homocysteine, and reactive oxyge…

… called sCD25. Its level can reflect T-cell activation. Follow the pathway Dr. Purser discusses sIL2R in sarcoidosis, granuloma formation, and other settings of immune activation. A high level is not specific to sarcoidosis; infection, oth…

…contributing to fibrosis when repair responses persist. Follow the pathway Dr. Purser connects TGF-β1 signaling with fibroblasts, collagen deposition, immune regulation, and oxidative stress. Its protective and harmful effects depend on ti…

…s and damaged tissue. It often works with TLR1 or TLR6. Follow the pathway Dr. Purser follows TLR2 signaling through MyD88 and NF-κB into cytokine production. This connects the initial recognition of a trigger with inflammation, blood-vess…

…rogrammed cell death, a normal quality-control process. Follow the pathway Dr. Purser connects DR4 signaling with damaged-cell removal, caspase activation, and the way cellular stress can affect the response. This is different from TNF-alp…

…g. At Purser Wellness, we believe in a personalized, Start Low, Go Slow approach. Sometimes you need methylated nutrients. Sometimes you need a smaller dose, a different form, or support for another pathway entirely. Watch the new video t…

…ls, it can act as a danger signal to the immune system. Follow the pathway Dr. Purser explains the connection between HMGB1, receptors such as RAGE and TLR4, NF-κB signaling, and ongoing tissue inflammation. He also discusses oxidative str…

…ells recognize and respond to double-strand DNA breaks. Follow the pathway Dr. Purser explains how the MRN complex recruits repair machinery such as ATM and connects DNA damage with oxidative stress. Research on cancer-related pathways doe…

… complex involved in activating inflammatory responses. Follow the pathway Dr. Purser describes the priming and activation steps, caspase-1, IL-1 beta, and IL-18. He connects these steps with gout, metabolic inflammation, and oxidative str…

…rt of the innate immune system’s early-warning network. Follow the pathway Dr. Purser connects TLR4 activation with NF-κB signaling, inflammatory cytokines, and the relationship between gut-barrier function and systemic immune activity. A …

…lutathione status actually is. If you've been dealing with low energy, increased oxidative stress, or you're simply looking to take a more proactive approach to your health, understanding your glutathione levels may provide valuable insigh…