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…s, imaging, and examination helps establish the diagnosis. Follow the pathway Dr. Purser discusses Th1 and Th17 cells, TNF-alpha, IL-6, IL-17, and oxidative stress around active lesions. He connects this with the blood–brain barrier and th…

…and the pathways that move methyl groups through the body. Follow the pathway Dr. Purser discusses rs2236225 and rs1076991, folate forms, homocysteine remethylation, and the relationship between folate demand and choline. Choline can also …

…5G promoter variation is commonly identified as rs1799889. Follow the pathway Dr. Purser discusses fibrinolysis, the process of dissolving clots, alongside homocysteine and blood-vessel inflammation. These are interacting risk consideratio…

…on Telogen effluvium is a pattern of hair shedding that can follow illness, physiological stress, weight change, medication changes, or other triggers. Hair changes often lag behind the trigger. Follow the pathway Dr. Purser discusses the …

…e cells and the cells that line tissues and blood vessels. Follow the pathway Dr. Purser connects TNF-alpha with joint, skin, and bowel inflammation, as well as oxidative stress. He discusses targeted TNF medicines and the separate role of…

…n change over time and with stress or other circumstances. Follow the pathway Dr. Purser discusses cortico-striatal-thalamo-cortical circuits, dopamine, and inhibitory GABA signaling. He also explores behavioral therapy, medicines, and sel…

…uch as C677T and A1298C can influence folate metabolism and methylation. Stop blaming yourself. Start understanding the biology. Support your nutrition. Support methylation when appropriate. Prioritize protein, fiber, and healthy fa…

…cal pathways involved in areas such as nutrient metabolism, methylation, and other cellular processes. Understanding those variations can give you and your healthcare team additional information to consider when making personalized wellne…

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…r look. MTHFR variants can influence folate metabolism and methylation, two processes involved in many functions throughout the body. That is exactly why personalized health matters. Your genes may provide clues. Your symptoms provide c…

… involved in allergies and defense against some parasites. Follow the pathway Dr. Purser connects eosinophil recruitment with allergic airway and skin inflammation. He also discusses research on CCL11 and brain aging; a research associatio…

…an attract monocytes, eosinophils, and other immune cells. Follow the pathway Dr. Purser explains how repeated immune-cell recruitment can sustain tissue inflammation. His teaching connects this pathway with allergic inflammation and discu…