CD40LG encodes CD40 ligand, which binds CD40 and supports communication needed for effective antibody responses. It is on the X chromosome, which changes how some genetic results must be interpreted.
Also called:
The ligand that helps acti…
…poprotein particles. This helps explain why the balance of HDL and other lipid particles is more complex than a single cholesterol number.
Also called:
Moving cholesterol between lipoproteins
CETP transfers cholesteryl esters between lipop…
CXCL13 is a chemokine that attracts cells expressing CXCR5, including B cells. This pairing helps organize immune-cell traffic in lymphoid tissues and some chronic inflammatory settings.
Also called:
Guiding B cells to organized immune sit…
CXCL8 is the gene for IL-8, a chemokine involved in recruiting and activating neutrophils. IL-8 is the protein nickname; CXCL8 is the gene name a DNA report may use.
Also called:
IL-8: bringing neutrophils to the response
CXCL8 is the gene…
CXCR5 encodes the receptor for CXCL13. This receptor helps guide B cells and certain T cells toward locations where organized immune responses develop.
Also called:
Following the CXCL13 signal
CXCR5 encodes the receptor for CXCL13. This re…
F5 encodes coagulation factor V. The well-characterized Factor V Leiden variant, rs6025, can make factor V less responsive to an anticoagulant control mechanism, increasing susceptibility to venous clots. It does not mean the body cannot ma…
F9 encodes coagulation factor IX. Disease-causing variants can result in hemophilia B, an inherited bleeding disorder, but a panel marker is not equivalent to a confirmed disease-causing finding.
Also called:
Factor IX and the bleeding sid…
GSTO2 encodes glutathione S-transferase omega 2, a redox enzyme with dehydroascorbate reductase activity that connects glutathione chemistry with vitamin C recycling. It is a separate gene from GSTO1.
Also called:
A distinct member of the …
IFNG encodes interferon gamma, a cytokine involved in cellular immune defense and activation of macrophages. It differs from the Th2 signals more often emphasized in allergic responses.
Also called:
Interferon gamma and macrophage activati…
IL10 encodes interleukin-10, a cytokine that can limit inflammatory responses and help prevent excessive immune-mediated tissue damage. Immune balance includes resolving a response as well as starting one.
Also called:
The immune system al…
IL12B encodes the p40 subunit shared by IL-12 and IL-23. This makes it an intersection between immune pathways rather than a stand-alone measure of one cytokine.
Also called:
A shared component of two cytokines
IL12B encodes the p40 subuni…
IL13 encodes interleukin-13, a cytokine involved in Th2 immune responses, mucus-related processes and tissue remodeling. It overlaps with some IL-4 functions but is not the same signal.
Also called:
Allergic signaling and tissue responses
…
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