Genes & pathways

Gene & pathway reference · FROM DR. PURSER’S TEACHING

F5

F5 encodes coagulation factor V. The well-characterized Factor V Leiden variant, rs6025, can make factor V less responsive to an anticoagulant control mechanism, increasing susceptibility to venous clots. It does not mean the body cannot make factor V.

Updated Sep 23, 2026 · Educational reference

THE TEACHING CONNECTION

Factor V Leiden concerns clot regulation

Factor V Leiden concerns clot regulation

F5 encodes coagulation factor V. The well-characterized Factor V Leiden variant, rs6025, can make factor V less responsive to an anticoagulant control mechanism, increasing susceptibility to venous clots. It does not mean the body cannot make factor V.

How Dr. Purser connects the pieces

Dr. Purser highlights this pathway when discussing clotting history and oral estrogen. The clinical importance depends on the confirmed result, whether one or two copies are present, previous clots and other risk factors. Discuss hormone and medication choices with the prescribing clinician rather than starting aspirin or an anticoagulant from a library page.

A question to bring to your visit

Does my confirmed Factor V Leiden result affect hormone choices or clot-prevention planning?

Variant lookup

These teaching identifiers include regional research markers. Match them to your original laboratory report; listing alone does not establish clinical significance or a treatment need.

Names you may see

Factor V · Factor V Leiden