Let’s explore “cytokines”

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling.

A subscriber post from Purser Wellness on Substack, covering cytokines and immune signaling, inflammation and antioxidants.

PURSER WELLNESSThe Hidden Molecule Driving Inflammation: Understanding the Purser Model of HomocysteineFrom the reading room

…mage. Instead, it acts as a marker of cytokine sensitivity. Cytokines are inflammatory signaling molecules released by immune cells. When homocysteine rises, it can trigger immune cells—especially monocytes and endothelial cells—to release …

PURSER WELLNESSMTHFR Mutations, Elevated Homocysteine & Autoimmune Inflammation: The Hidden Root Cause Most Doctors MissFrom the reading room

…homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amplifier.” When levels climb above 10–12 µmol/L (my functional optimum is <7–8 µmol/L), hom…

PURSER WELLNESSHow To Know If You Have High Homocysteine?A conversation with Dr. Purser

…eted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.

…cause severe MTHFR deficiency. Topics: homocysteine, pain, cytokines, chronic pain, neuroinflammation, oxidative stress

…utathione, monocytes, IL-8, MCP-1, reactive oxygen species, cytokines

… The chapter brings together oxidative stress, inflammatory cytokines and kidney injury, then discusses VARS Glutathione as a possible intervention. It is a route into the author’s model and the difference between a mechanistic rationale, a…

…8, occult infection, persistent inflammation, homocysteine, cytokines

…from symptoms and family history to genes, homocysteine and cytokines. Each transition is a question requiring evidence. A symptom does not confirm a genetic explanation; a variant does not prove an abnormal blood result; and an abnormal re…

Encodes diamine oxidase, an enzyme involved in breaking down histamine and other amines. DAO is used here as an enzyme nickname; it is also the official symbol of a different gene.