Many vitamins and minerals go through the methylation cycle meaning a methyl group is added to a molecule to turn it into its active form. Individuals with MTHFR and other genetic methylation errors are unable to efficiently create the methylated versions of those certain vitamins and minerals. Those with MTHFR specifically cannot make enough 5-MTHF, an activated form of folate, which in turn prohibits the ability to methylate other vitamins.
These errors can lead to a number of cellular deficiencies which can cause chronic fatigue, anxiety, depression (BASICALLY MAKE YOU FEEL LIKE A SLUG) and
…cysteine metabolism.
These genes affect pathways involving:
methylation
folate metabolism
redox balance
the transsulfuration pathway
glutathione production
When certain variants occur in a homozygous state, they can significantly increase a…
…(5-methyltetrahydrofolate). The downstream result? Impaired methylation, elevated plasma homocysteine, and a body-wide amplification of inflammatory cytokines. Homocysteine is not merely a cardiovascular marker. It is a potent “cytokine amp…
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