Let’s explore “MTHFR”

PURSER WELLNESSGENOVA™ Neopterin Biopterin Urine Profile for MTHFRFrom the reading room

Excessive Neopterin NEGATIVELY impacts the Nitric Oxide pathway in the body

PURSER WELLNESSGlutathione and Your Ability To Detox?A conversation with Dr. Purser

Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine storms. That’s why VARS Glutathione is such a breakthrough: it’s reduced, functional, and proven to lower harmful cytokines like IL-8 and MCP-1, giving your body the detox power it needs. After 15 years of research and real patient results, it’s the only oral glutathione that actually works where it matters—inside your cells.

PURSER WELLNESSWhat Causes Chronic Fatigue Syndrome?A conversation with Dr. Purser

Do you know what causes chronic fatigue? Dr. Purser explains the top causes of Chronic Fatigue Syndrome (CFS) and shares what steps to take to feel normal again. Discover why CFS is a symptom of underlying conditions and what the treatment of underlying causes of CFS includes. Dr. Purser dispels the myth of medication deficiency related to CFS symptoms. Discover the relationship of nutritional deficiencies, hormone imbalance, and poorly understood genetic causes from MTHFR deficiency to fatigue. Learn what contributes to fatigue when the absorption of Vitamin B12, folate, pantothenate, and oth

PURSER WELLNESSFill the Holes of Methylation #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/mthfr-and-the-never-ending-sugar?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=0BGJ_m5Cbrc #shorts #substack

PURSER WELLNESSOVER-METHYLATION - Are Your B Vitamins Hurting You?A conversation with Dr. Purser

Can the B vitamins you are taking to support energy and methylation eventually make you feel worse? In this video, Jackson Larkin explains what practitioners often call “overmethylation,” a possible adverse response to supplemental methyl donors such as: • 5-MTHF or methylfolate • Methylcobalamin • Trimethylglycine, also called TMG • Multiple overlapping methylation formulas Possible warning signs can include irritability, anxiety, restlessness, insomnia, brain fog, fatigue, and feeling “wired but tired.” These symptoms do not prove that you are overmethylated. They can have many possible causes. The timing of symptoms, your total supplement exposure, nutrient status, genetics, medications, and health history all need to be considered. In this video, we discuss: • Why methylation is essential • How methyl-donor supplements support the body • Why the right vitamin can become the wrong dose • Ingredients to look for on your supplement labels • Why some people may need lower doses or non-methylated forms • How genetics and intracellular nutrient testing can guide a more personalized plan At Purser Wellness, we believe in a Start Low, Go Slow approach. The goal is not to eliminate methylation. The goal is to provide the right form and amount of support for each individual. Learn more or schedule with Purser Wellness: https://danpursermd.com Educational content only. Do not discontinue prescribed or medically necessary supplements without consulting your qualified healthcare professional. #Overmethylation #MTHFR #Methylation #B12 #Methylfolate #VitaminB12 #TMG #BrainFog #FunctionalMedicine #PurserWellness Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

PURSER WELLNESSWhere To Find Dr. Purser Online (Deplatformed)A conversation with Dr. Purser

Dr. Dan Purser here with an important update from Purser Wellness. Earlier this week we were deplatformed on a major platform right after discussing groundbreaking findings from our homocysteine research — particularly its connections to ASD, ADHD, cytokine issues, and inflammatory conditions like polymyalgia rheumatica (PMR). Despite losing access to our old page (and nearly 200,000 followers), we’re back stronger with a brand new official page! ✅ Follow our new official Facebook page here: https://www.facebook.com/purserwellness We’re keeping things focused and continuing our important work on root-cause wellness, intracellular nutrient deficiencies, genetics, glutathione/SOD balance, and more. ### Where to Stay Connected: - Substack (Daily research articles & in-depth content): https://substack.com/PurserWellness or https://danpursermd.substack.com - YouTube – Live streams and full recordings will continue here (plus TikTok, Instagram, and podcast platforms) Dr. Purser’s message is clear: We will not stop the research. “I’ll quit when I die… and maybe not even then.” If you’ve been following our work on homocysteine, MTHFR, cytokine problems, hormone optimization, and functional medicine protocols, please: - Like and follow the new Facebook page - Subscribe to Substack - Share this video with friends and patients who need this information Thank you for your incredible support during this transition. Your follows and shares help us keep delivering the cutting-edge research no one else is doing. 👉 New Facebook Page: https://www.facebook.com/purserwellness Purser Wellness Root-Cause Medicine • Genetics • Homocysteine Research danpursermd.com #DrDanPurser #PurserWellness #Homocysteine #FunctionalMedicine #RootCauseHealth #CytokineResearch #ASD #ADHD #MTHFR

PURSER WELLNESSAutism Answered - Root Cause Solved with #1 Reviewed MD in the USAA conversation with Dr. Purser

Hi, I’m Dr. Dan Purser. For too long, autism has been treated as a mystery with only symptom management. In this episode, I break down what I’ve seen consistently in practice: the real root cause behind many cases on the spectrum. It starts with genetic variants (especially MTHFR and related SNPs) that break the transsulfuration pathway. When kids can’t efficiently convert homocysteine into glutathione, they lose their ability to detox heavy metals and environmental toxins. The result is chronic inflammation, oxidative stress, and developmental challenges. The good news? Once we identify these biochemical and genetic imbalances through proper testing, we can intervene at the root with targeted support — restoring methylation, rebuilding glutathione function, and giving the body what it needs to heal. This isn’t theory. It’s the Purser Method® in action. If you’re a parent searching for real answers instead of just labels, this episode is for you. The root cause has been solved. Now let’s talk solutions.

PURSER WELLNESSHow to Properly Treat Kids: Root Cause Medicine for Autism, ADHD, and Developmental ChallengesA conversation with Dr. Purser

In this powerful live session, Dr. Dan Purser MD reveals why conventional pediatric medicine often falls short and shares his proven Purser Method® for helping children with autism spectrum traits, severe ADHD, chronic inflammation, and developmental delays. Drawing from over 43 years of clinical experience, Dr. Purser explains: Why genetic testing (especially MTHFR and related SNPs) is the essential first step How to use targeted, active-form nutrients instead of generic vitamins The role of leucovorin (high-dose folinic acid) and when it makes a real difference Practical ways to reduce toxin load and calm the inflammatory response Smart strategies around vaccination and detoxification support Dr. Purser emphasizes that kids are not little adults — their developing systems need precise, individualized care. Parents and practitioners will walk away with actionable steps that address root causes rather than just managing symptoms. Whether your child is struggling with speech delays, meltdowns, focus issues, or recurrent health problems, this episode offers real hope through biochemistry done right. Resources Mentioned: Pediatric MTHFR formulas: https://www.PhysicianDesigned.com Book a consultation: http://www.DanPurserMD.com Dr. Purser’s books on Amazon: https://www.amazon.com/-/e/B00BIKSGVQ If you’re a parent tired of “there’s nothing more we can do,” or a practitioner looking for better tools, this episode is for you. Timestamps available in the full video. Subscribe, leave a review, and share this with any parent who needs to hear it. The kids deserve better answers. Dan Purser MD – Root Cause Inflammation & Genetic Optimization #MTHFR #Autism #ADHD #ChildrensHealth #Leucovorin #FunctionalMedicine #Pediatrics Follow Dr. Purser! Info: http://www.DanPurserMD.com Supplements: https://www.PhysicianDesigned.com Books: https://www.amazon.com/-/e/B00BIKSGVQ Facebook: https://www.facebook.com/danpursermd Facebook: https://www.facebook.com/PhysicianDesigned Twitter: https://twitter.com/realdanpursermd YouTube: https://www.youtube.com/danpursermd Instagram: https://www.instagram.com/danpurser.md Pinterest: https://www.pinterest.com/danpursermd

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step

PURSER WELLNESSCan Glutathione Reverse Kidney Disease, Lower Blood Pressure, and Calm Cytokine Storms? What High HA conversation with Dr. Purser

The Overlooked Link Between MTHFR Mutations, Hyperhomocysteinemia, PCOS, Fibromyalgia, Chronic Inflammation, and Renal Decline — and Why Precision Genetic Testing May Be the Missing Step https://danpursermd.substack.com/p/can-glutathione-reverse-kidney-disease?utm_source=youtube

PURSER WELLNESSWhy Homocysteine Breaks Your Detox #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=HuQbQ1IqNIM #shorts #substack

PURSER WELLNESSHomocysteine: Hidden Killer #substack #shortsA conversation with Dr. Purser

This is a clip from https://danpursermd.substack.com/p/high-homocysteine-mthfr-mutations?utm_source=youtube_shorts See the full video: https://www.youtube.com/watch?v=HuQbQ1IqNIM #shorts #substack